FGF10
Fibroblast growth factor 10
Protein Summary
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 502.45 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 389 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 502.45 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 389 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 107
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (191)
ITIH2
Novelty: 0.04886358
p_int: 0.996760059
p_ni: 0.003239939
p_wrong: 2e-9
Score: 0.222
Data Source: BioPlex,STRINGDB
SIRT1
Family: Epigenetic
Novelty: 0.00022265
p_int: 0.860939249
p_ni: 0.139060751
Score: 0.203
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Downstream (18)
1 – 5 of 18
FGFR1
Pathways (105)
Reactome (52)
KEGG (9)
PathwayCommons (8)
WikiPathways (36)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated point mutants of FGFR2 | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated point mutants of FGFR2 | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Developmental Biology | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (112)
Functions (9)
Components (5)
Processes (98)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vital capacity | 1 | 1 | 1 | 67.3 | |||||
forced expiratory volume | 1 | 1 | 1 | 57.8 | |||||
1 | 1 | 0 | 1.1 | 36.5 | |||||
2 | 1 | 0 | 1.1 | 24.5 | |||||
balding measurement | 1 | 1 | 1 | 3.3 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vital capacity | 1 | 67.3 | |||||
forced expiratory volume | 1 | 57.8 | |||||
0 | 1.1 | 36.5 | |||||
0 | 1.1 | 24.5 | |||||
balding measurement | 1 | 3.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1099809 | 14165 | ||||||
Rat | RGD:2606 | 25443 | ||||||
Dog | fibroblast growth factor 10 | VGNC:40839 | 612454 | |||||
Horse | fibroblast growth factor 10 | VGNC:18009 | 100052655 | |||||
Pig | fibroblast growth factor 10 | 100525086 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | fibroblast growth factor 10 | |||||
Horse | fibroblast growth factor 10 | |||||
Pig | fibroblast growth factor 10 | |||||
Publication Statistics
PubMed Score 502.45
PubMed score by year
PubTator Score 198.44
PubTator score by year
Related Publications
Text Mined References (99)
GeneRif Annotations (60)
Items per page:
0 of 0
PMID | Year | Title |
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