FGF10
Fibroblast growth factor 10
Protein Classes
Protein Summary
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 488.8 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 389 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 488.8 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 389 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 107
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
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1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vital capacity | 1 | 1 | 1 | 56.2 | |||||
forced expiratory volume | 1 | 1 | 1 | 42.7 | |||||
prostate carcinoma | 2 | 1 | 0 | 1.1 | 41.4 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vital capacity | 1 | 56.2 | |||||
forced expiratory volume | 1 | 42.7 | |||||
prostate carcinoma | 0 | 1.1 | 41.4 | ||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1099809 | 14165 | ||||||
Rat | RGD:2606 | 25443 | ||||||
Dog | fibroblast growth factor 10 | VGNC:40839 | 612454 | |||||
Horse | fibroblast growth factor 10 | VGNC:18009 | 100052655 | |||||
Pig | fibroblast growth factor 10 | 100525086 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | fibroblast growth factor 10 | |||||
Horse | fibroblast growth factor 10 | |||||
Pig | fibroblast growth factor 10 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (105)
Reactome (52)
KEGG (9)
PathwayCommons (8)
WikiPathways (36)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 52
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated point mutants of FGFR2 | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated point mutants of FGFR2 | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Developmental Biology | ||||
Disease | ||||
Gene Ontology Terms (112)
Functions (9)
Components (5)
Processes (98)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (191)
1 – 10 of 191
HIST1H1A
Novelty: 0.00123818
p_int: 0.997786647
p_ni: 0.002213353
Data Source: BioPlex
ITIH2
Novelty: 0.04886358
p_int: 0.996760059
p_ni: 0.003239939
p_wrong: 2e-9
Score: 0.222
Data Source: BioPlex,STRINGDB
RPL26L1
Novelty: 0.75408617
p_int: 0.955181284
p_ni: 0.044818716
Data Source: BioPlex
SIRT1
Family: Epigenetic
Novelty: 0.00022265
p_int: 0.860939249
p_ni: 0.139060751
Score: 0.203
Data Source: BioPlex,STRINGDB
FGFR2
Family: Kinase
Novelty: 0.00066613
Score: 0.998
Data Source: Reactome,STRINGDB
FGFBP1
Novelty: 0.02117534
Score: 0.966
Data Source: Reactome,STRINGDB
FGFRL1
Novelty: 0.02178846
Score: 0.966
Data Source: STRINGDB
FGFR1
Family: Kinase
Novelty: 0.00055714
Score: 0.963
Data Source: STRINGDB
PTPN11
Family: Enzyme
Novelty: 0.00073124
Score: 0.959
Data Source: STRINGDB
FRS2
Novelty: 0.00654052
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score 488.80
PubMed score by year
PubTator Score 198.44
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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