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Tbio
CFLAR
CASP8 and FADD-like apoptosis regulator

Protein Summary
Description
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309955
  • ENSP00000312455
  • ENSG00000003402
  • ENST00000341222
  • ENSP00000339335
  • ENST00000341582
  • ENSP00000345807
  • ENST00000342795
  • ENSP00000342809
  • ENST00000423241
  • ENSP00000399420
  • ENST00000440180
  • ENSP00000406775
  • ENST00000443227
  • ENSP00000413270
  • ENST00000457277
  • ENSP00000411535
  • ENST00000479953
  • ENSP00000471805

Symbol
  • CASH
  • CASP8AP1
  • CLARP
  • MRIT
  • CASH
  • FLIP
  • MRIT
  • CLARP
  • FLAME
  • cFLIP
  • Casper
  • FLAME1
  • c-FLIP
  • FLAME-1
  • I-FLICE
  • c-FLIPL
  • c-FLIPR
  • c-FLIPS
  • CASP8AP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
biological process
0.94
transcription factor binding site profile
0.93
chemical
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.83   (req: < 5)
Gene RIFs: 278   (req: <= 3)
Antibodies: 884   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.83   (req: >= 5)
Gene RIFs: 278   (req: > 3)
Antibodies: 884   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
71.6
1
1
0
1.1
69.8
myeloid white cell count
1
1
1
66
4
4
0
1.2
65.5
leukocyte count
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
71.6
0
1.1
69.8
myeloid white cell count
1
66
0
1.2
65.5
leukocyte count
1
63.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CASP8 and FADD like apoptosis regulator
VGNC:133
459872
Macaque
CASP8 and FADD like apoptosis regulator
574234
Mouse
MGI:1336166
12633
Rat
RGD:620847
117279
Dog
CASP8 and FADD like apoptosis regulator
VGNC:39178
488471
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CASP8 and FADD like apoptosis regulator
Macaque
CASP8 and FADD like apoptosis regulator
Mouse
Rat
Dog
CASP8 and FADD like apoptosis regulator
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15519-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (166)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Death Receptor Signalling
Gene Ontology Terms (47)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (158)
1 – 10 of 158
PLIN5
Tbio
Novelty:  0.01265845
p_int:  0.999996885
p_ni:  0.000003115
Score:  0.538
Data Source:  BioPlex,STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
p_int:  0.999978129
p_ni:  0.000021731
p_wrong:  1.41e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
TNFRSF10B
Tbio
Novelty:  0.00054433
Score:  0.999
Data Source:  Reactome,STRINGDB
FAS
Tbio
Novelty:  0.00043286
Score:  0.999
Data Source:  Reactome,STRINGDB
TNFRSF10A
Tchem
Novelty:  0.0003383
Score:  0.999
Data Source:  Reactome,STRINGDB
FADD
Tbio
Novelty:  0.00137968
Score:  0.996
Data Source:  Reactome,STRINGDB
CASP10
Tchem
Family:  Enzyme
Novelty:  0.00724061
Score:  0.99
Data Source:  STRINGDB
TNFSF10
Tchem
Novelty:  0.00096612
Score:  0.982
Data Source:  Reactome,STRINGDB
FASLG
Tbio
Novelty:  0.0003303
Score:  0.981
Data Source:  Reactome,STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.979
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  1050.83

PubMed score by year
PubTator Score  2415.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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