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Tbio
CFLAR
CASP8 and FADD-like apoptosis regulator

Protein Summary
Description
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309955
  • ENSP00000312455
  • ENSG00000003402
  • ENST00000341222
  • ENSP00000339335
  • ENST00000341582
  • ENSP00000345807
  • ENST00000342795
  • ENSP00000342809
  • ENST00000423241
  • ENSP00000399420
  • ENST00000440180
  • ENSP00000406775
  • ENST00000443227
  • ENSP00000413270
  • ENST00000457277
  • ENSP00000411535
  • ENST00000479953
  • ENSP00000471805

Symbol
  • CASH
  • CASP8AP1
  • CLARP
  • MRIT
  • CASH
  • FLIP
  • MRIT
  • CLARP
  • FLAME
  • cFLIP
  • Casper
  • FLAME1
  • c-FLIP
  • FLAME-1
  • I-FLICE
  • c-FLIPL
  • c-FLIPR
  • c-FLIPS
  • CASP8AP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
biological process
0.94
transcription factor binding site profile
0.93
chemical
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1164.59   (req: < 5)
Gene RIFs: 278   (req: <= 3)
Antibodies: 884   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1164.59   (req: >= 5)
Gene RIFs: 278   (req: > 3)
Antibodies: 884   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0