CFLAR
CASP8 and FADD-like apoptosis regulator
Protein Summary
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
- ENST00000309955
- ENSP00000312455
- ENSG00000003402
- ENST00000341222
- ENSP00000339335
- ENST00000341582
- ENSP00000345807
- ENST00000342795
- ENSP00000342809
- ENST00000423241
- ENSP00000399420
- ENST00000440180
- ENSP00000406775
- ENST00000443227
- ENSP00000413270
- ENST00000457277
- ENSP00000411535
- ENST00000479953
- ENSP00000471805
- CASH
- CASP8AP1
- CLARP
- MRIT
- CASH
- FLIP
- MRIT
- CLARP
- FLAME
- cFLIP
- Casper
- FLAME1
- c-FLIP
- FLAME-1
- I-FLICE
- c-FLIPL
- c-FLIPR
- c-FLIPS
- CASP8AP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
virus perturbation | 1 | ||
biological process | 0.94 | ||
transcription factor binding site profile | 0.93 | ||
chemical | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1164.59 (req: < 5)
Gene RIFs: 301 (req: <= 3)
Antibodies: 884 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1164.59 (req: >= 5)
Gene RIFs: 301 (req: > 3)
Antibodies: 884 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 41
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0