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Tbio
CLOCK
Circadian locomoter output cycles protein kaput

Protein Summary
Description
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309964
  • ENSP00000308741
  • ENSG00000134852
  • ENST00000381322
  • ENSP00000370723
  • ENST00000513440
  • ENSP00000426983

Symbol
  • BHLHE8
  • KIAA0334
  • KAT13D
  • bHLHe8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.98
co-expressed gene
0.89
cell type or tissue
0.85
microRNA
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.62   (req: < 5)
Gene RIFs: 173   (req: <= 3)
Antibodies: 450   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.62   (req: >= 5)
Gene RIFs: 173   (req: > 3)
Antibodies: 450   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
14
15
94.9
BMI-adjusted waist-hip ratio
4
13
15
94.4
hip circumference
1
7
7
86.8
BMI-adjusted hip circumference
2
11
11
81.7
waist circumference
1
2
2
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
15
94.9
BMI-adjusted waist-hip ratio
15
94.4
hip circumference
7
86.8
BMI-adjusted hip circumference
11
81.7
waist circumference
2
63.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99698
12753
Rat
RGD:620271
60447
Dog
clock circadian regulator
VGNC:39353
475145
Horse
clock circadian regulator
VGNC:16627
100034166
Cow
clock circadian regulator
VGNC:27456
100300400
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
clock circadian regulator
Horse
clock circadian regulator
Cow
clock circadian regulator
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15516-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Circadian Clock
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Chromatin modifying enzymes
Chromatin organization
Circadian Clock
HATs acetylate histones
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (145)
1 – 10 of 145
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.99999995
p_ni:  5e-8
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
p_int:  0.999999503
p_ni:  4.97e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CIPC
Tdark
Novelty:  0.02263148
p_int:  0.999998242
p_ni:  0.000001757
p_wrong:  2e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999995492
p_ni:  0.000004488
p_wrong:  2e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
TEKT4
Tbio
Novelty:  0.05559086
p_int:  0.999683425
p_ni:  0.000249772
p_wrong:  0.000066803
Score:  0.211
Data Source:  BioPlex,STRINGDB
SRGAP3
Tbio
Family:  Enzyme
Novelty:  0.01913784
p_int:  0.999531401
p_ni:  0.000434
p_wrong:  0.0000346
Score:  0.282
Data Source:  BioPlex,STRINGDB
CRY1
Tchem
Novelty:  0.00116593
Score:  0.999
Data Source:  Reactome,STRINGDB
CRY2
Tbio
Novelty:  0.00156961
Score:  0.999
Data Source:  Reactome,STRINGDB
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
Score:  0.997
Data Source:  Reactome,STRINGDB
BHLHE41
Tbio
Family:  TF
Novelty:  0.01015053
Score:  0.994
Data Source:  STRINGDB
Publication Statistics
PubMed Score  618.62

PubMed score by year
PubTator Score  486.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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