CLOCK
Circadian locomoter output cycles protein kaput
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
biological process | 0.98 | ||
co-expressed gene | 0.89 | ||
cell type or tissue | 0.85 | ||
microRNA | 0.84 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Circadian Clock | ||||
Reactome | HATs acetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Circadian Clock | ||||
HATs acetylate histones | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
waist-hip ratio | 3 | 14 | 15 | 94.9 | |||||
BMI-adjusted waist-hip ratio | 4 | 13 | 15 | 94.4 | |||||
hip circumference | 1 | 7 | 7 | 86.8 | |||||
BMI-adjusted hip circumference | 2 | 11 | 11 | 81.7 | |||||
waist circumference | 1 | 2 | 2 | 63.9 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
waist-hip ratio | 15 | 94.9 | |||||
BMI-adjusted waist-hip ratio | 15 | 94.4 | |||||
hip circumference | 7 | 86.8 | |||||
BMI-adjusted hip circumference | 11 | 81.7 | |||||
waist circumference | 2 | 63.9 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:99698 | 12753 | ||||||
Rat | RGD:620271 | 60447 | ||||||
Dog | clock circadian regulator | VGNC:39353 | 475145 | |||||
Horse | clock circadian regulator | VGNC:16627 | 100034166 | |||||
Cow | clock circadian regulator | VGNC:27456 | 100300400 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | clock circadian regulator | |||||
Horse | clock circadian regulator | |||||
Cow | clock circadian regulator | |||||
PMID | Year | Title |
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