Tbio POLR2D DNA-directed RNA polymerase II subunit RPB4

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15514
• Q52LT4
• RNA polymerase II subunit B4

Gene Name

• POLR2D

Ensembl ID

• ENST00000272645
• ENSP00000272645
• ENSG00000144231

Symbol

• RBP4
• RPB16
• HSRBP4
• HSRPB4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
disease perturbation	0.9
kinase perturbation	0.88
transcription factor perturbation	0.84
histone modification site profile	0.81

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Dna-directed Rna Polymerase Ii Subunit Rpb4

DTO Classes

Protein / Transcription Factor / Dna-directed Rna Polymerase Ii Subunit Rpb4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.31   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.31   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0