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Tbio
ARPC5
Actin-related protein 2/3 complex subunit 5

Protein Summary
Description
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294742
  • ENSP00000294742
  • ENSG00000162704
  • ENST00000359856
  • ENSP00000352918

Symbol
  • ARC16
  • ARC16
  • p16-Arc
  • dJ127C7.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.99
virus perturbation
0.97
kinase perturbation
0.88
transcription factor binding site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.52   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.52   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
2
97.2
1
1
0
1.4
66.8
1
1
0
1.4
63.7
1
1
0
1.4
63.7
1
1
0
1.4
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
97.2
0
1.4
66.8
0
1.4
63.7
0
1.4
63.7
0
1.4
63.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 5
VGNC:6725
457574
Mouse
MGI:1915021
67771
Rat
RGD:1311791
360854
Dog
actin related protein 2/3 complex subunit 5
VGNC:53328
480037
Horse
actin related protein 2/3 complex subunit 5
VGNC:15539
100051848
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 5
Mouse
Rat
Dog
actin related protein 2/3 complex subunit 5
Horse
actin related protein 2/3 complex subunit 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15511-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (33)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Gene Ontology Terms (29)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (218)
1 – 10 of 218
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.999942583
p_ni:  0.000057393
p_wrong:  2.4e-8
Data Source:  BioPlex
ACTR3B
Tbio
Novelty:  0.06033214
p_int:  0.999885491
p_ni:  0.000114509
Score:  0.969
Data Source:  BioPlex,STRINGDB
RBCK1
Tbio
Novelty:  0.02760333
p_int:  0.999241308
p_ni:  0.000743445
p_wrong:  0.000015247
Score:  0.163
Data Source:  BioPlex,STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
p_int:  0.999021034
p_ni:  0.000978966
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC1A
Tbio
Novelty:  0.07577807
p_int:  0.998625616
p_ni:  0.001374384
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRO
Tbio
Novelty:  0.02850833
p_int:  0.998405664
p_ni:  0.001594336
Data Source:  BioPlex
ARPC1B
Tbio
Novelty:  0.03873325
p_int:  0.997662988
p_ni:  0.002337012
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.99666982
p_ni:  0.00333018
Score:  0.999
Data Source:  BioPlex,STRINGDB
VPS13A
Tbio
Novelty:  0.00581335
p_int:  0.991424829
p_ni:  0.008575171
Score:  0.179
Data Source:  BioPlex,STRINGDB
PRKD2
Tchem
Family:  Kinase
Novelty:  0.03143723
p_int:  0.984939897
p_ni:  0.015017154
p_wrong:  0.000042949
Score:  0.183
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  25.52

PubMed score by year
PubTator Score  7.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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