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Tbio
YKT6
Synaptobrevin homolog YKT6

Protein Summary
Description
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223369
  • ENSP00000223369
  • ENSG00000106636
  • ENST00000496112
  • ENSP00000420805
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
cellular component
0.87
interacting protein
0.82
transcription factor binding site profile
0.76
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (322)
PTAR1
Tdark
Family:  Enzyme
Novelty:  0.37120559
p_int:  0.999997801
p_ni:  0.000002198
Score:  0.82
Data Source:  BioPlex,STRINGDB
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.999994704
p_ni:  0.000005296
Data Source:  BioPlex
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999590652
p_ni:  0.000392619
p_wrong:  0.000016729
Score:  0.96
Data Source:  BioPlex,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.999520342
p_ni:  0.000479658
Score:  0.156
Data Source:  BioPlex,STRINGDB
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
p_int:  0.99926544
p_ni:  0.000734247
p_wrong:  3.13e-7
Data Source:  BioPlex
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.989983442
p_ni:  0.010015883
p_wrong:  6.75e-7
Score:  0.458
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.989677468
p_ni:  0.010322044
p_wrong:  4.88e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.987659612
p_ni:  0.012340237
p_wrong:  1.51e-7
Data Source:  BioPlex
C1QL1
Tdark
Novelty:  0.11689088
p_int:  0.980735754
p_ni:  0.01896164
p_wrong:  0.000302606
Data Source:  BioPlex
STX11
Tbio
Novelty:  0.01670743
p_int:  0.980427313
p_ni:  0.019572493
p_wrong:  1.94e-7
Score:  0.866
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
12
17
25
99.9
glucose measurement
7
16
17
99.8
fasting blood glucose measurement
12
7
18
99
birth weight
5
3
6
96.6
9
7
8
1.1
95.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
25
99.9
glucose measurement
17
99.8
fasting blood glucose measurement
18
99
birth weight
6
96.6
8
1.1
95.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YKT6 v-SNARE homolog
463919
Macaque
YKT6 v-SNARE homolog
699606
Mouse
MGI:1927550
56418
Rat
RGD:70897
64351
Dog
synaptobrevin homolog YKT6
475497
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YKT6 v-SNARE homolog
Macaque
YKT6 v-SNARE homolog
Mouse
Rat
Dog
synaptobrevin homolog YKT6
Publication Statistics
PubMed Score 66.38
PubMed score by year
PubTator Score 32.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title