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Tchem
PLA2G10
Group 10 secretory phospholipase A2

Protein Summary
Description
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000438167
  • ENSP00000393847
  • ENSG00000069764
  • ENST00000621727
  • ENSP00000479397
  • ENSG00000276870

Symbol
  • SPLA2
  • GXPLA2
  • GXSPLA2
  • sPLA2-X
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.96
biological process
0.94
gene perturbation
0.82
PubMedID
0.69
phenotype
0.58


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.77   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.77   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (32)
1 – 10 of 32
CHEMBL148674
chemical structure image
CHEMBL148649
chemical structure image
CHEMBL515637,CHEMBL435488
chemical structure image
CHEMBL446349
chemical structure image
CHEMBL208315
chemical structure image
CHEMBL514692
chemical structure image
CHEMBL506485
chemical structure image
CHEMBL514705
chemical structure image
CHEMBL220842
chemical structure image
CHEMBL223880
chemical structure image
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1347522
26565
Rat
RGD:61935
29359
Dog
phospholipase A2 group X
VGNC:54056
489997
Horse
phospholipase A2 group X [Source:HGNC Symbol;Acc:HGNC:9029]
Cow
group 10 secretory phospholipase A2
613966
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phospholipase A2 group X
Horse
phospholipase A2 group X [Source:HGNC Symbol;Acc:HGNC:9029]
Cow
group 10 secretory phospholipase A2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15496-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Gene Ontology Terms (31)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (142)
1 – 10 of 142
GPT2
Tbio
Family: Enzyme
Novelty: 0.00478585
p_int: 0.999999767
p_ni: 2.13e-7
p_wrong: 2e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
GSTCD
Tbio
Family: Enzyme
Novelty: 0.11613228
p_int: 0.999996887
p_ni: 0.0000031
p_wrong: 1.2e-8
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.999991925
p_ni: 0.000008075
Data Source: BioPlex
TDP2
Tchem
Family: Enzyme
Novelty: 0.01104303
p_int: 0.999957587
p_ni: 0.000042412
p_wrong: 1e-9
Data Source: BioPlex
WNT11
Tbio
Novelty: 0.0045754
p_int: 0.999913042
p_ni: 0.000083127
p_wrong: 0.000003832
Score: 0.177
Data Source: BioPlex,STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
p_int: 0.999908985
p_ni: 0.000091002
p_wrong: 1.2e-8
Data Source: BioPlex
EOGT
Tbio
Family: Enzyme
Novelty: 0.08290891
p_int: 0.99973212
p_ni: 0.000267474
p_wrong: 4.06e-7
Data Source: BioPlex
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.99963768
p_ni: 0.00036232
Data Source: BioPlex
ZSWIM7
Tbio
Novelty: 0.45694042
p_int: 0.999547132
p_ni: 1.17e-7
p_wrong: 0.000452751
Score: 0.558
Data Source: BioPlex,STRINGDB
UBA52
Tbio
Novelty: 0.01637744
p_int: 0.999410418
p_ni: 0.000540877
p_wrong: 0.000048705
Data Source: BioPlex
Publication Statistics
PubMed Score  411.77

PubMed score by year
PubTator Score  176.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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