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Tbio
GYG2
Glycogenin-2

Protein Summary
Description
Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353656
  • ENSP00000487294
  • ENSG00000056998
  • ENST00000381163
  • ENSP00000370555
  • ENST00000398806
  • ENSP00000381786

Symbol
  • GN2
  • GN-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
tissue
0.56
cell line
0.5
small molecule perturbation
0.48
microRNA
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
81.8
low density lipoprotein cholesterol measurement
1
1
1
77.1
body height
2
1
2
52.7
mean corpuscular volume
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
81.8
low density lipoprotein cholesterol measurement
1
77.1
body height
2
52.7
mean corpuscular volume
1
7.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycogenin 2
VGNC:12391
465469
Macaque
glycogenin 2
720568
Dog
glycogenin 2
VGNC:41573
491717
Horse
glycogenin 2
VGNC:18669
100064536
Cow
glycogenin 2
VGNC:29729
505258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycogenin 2
Macaque
glycogenin 2
Dog
glycogenin 2
Horse
glycogenin 2
Cow
glycogenin 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15488-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Protein-Protein Interactions (63)
1 – 10 of 63
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.999999332
p_ni:  6.29e-7
p_wrong:  3.9e-8
Score:  0.605
Data Source:  BioPlex,STRINGDB
OSCP1
Tbio
Novelty:  0.05361924
p_int:  0.999993651
p_ni:  0.000006329
p_wrong:  2.1e-8
Score:  0.816
Data Source:  BioPlex,STRINGDB
DACH2
Tbio
Novelty:  0.0806643
p_int:  0.999982445
p_ni:  0.000017553
p_wrong:  3e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
GYS1
Tchem
Family:  Enzyme
Novelty:  0.00721964
p_int:  0.999958277
p_ni:  0.000041723
Score:  0.996
Data Source:  BioPlex,STRINGDB
AMY2A
Tclin
Family:  Enzyme
Novelty:  0.00132709
p_int:  0.99993328
p_ni:  0.000028788
p_wrong:  0.000037932
Score:  0.172
Data Source:  BioPlex,STRINGDB
NONO
Tbio
Novelty:  0.00501502
p_int:  0.99989458
p_ni:  0.000105293
p_wrong:  1.27e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
GYG1
Tbio
Family:  Enzyme
Novelty:  0.01446978
p_int:  0.998748705
p_ni:  0.001251295
Score:  0.968
Data Source:  BioPlex,STRINGDB
SIRT5
Tchem
Family:  Epigenetic
Novelty:  0.00225239
p_int:  0.995233294
p_ni:  0.004766704
p_wrong:  2e-9
Score:  0.17
Data Source:  BioPlex,STRINGDB
RAE1
Tbio
Novelty:  0.01342883
p_int:  0.990452976
p_ni:  0.009547024
Score:  0.163
Data Source:  BioPlex,STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
p_int:  0.98690382
p_ni:  0.012787982
p_wrong:  0.000308197
Score:  0.173
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  69.05

PubMed score by year
PubTator Score  37.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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