Tbio GYG2 Glycogenin-2

Protein Summary

Description

Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• O15488
• B7WNN6
• O15485
• O15486
• O15487
• O15489
• O15490
• GN-2

Gene Name

• GYG2

Ensembl ID

• ENST00000353656
• ENSP00000487294
• ENSG00000056998
• ENST00000381163
• ENSP00000370555
• ENST00000398806
• ENSP00000381786

Symbol

• GN2
• GN-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.73
tissue	0.56
cell line	0.5
small molecule perturbation	0.48
microRNA	0.46

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Glycogenin-2

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Glycogenin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.05   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 160   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.05   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (63)

Explore Interacting Targets

1 – 10 of 63

• See Interactions on String-DB

STBD1

Tbio

Novelty:  0.08362185

p_int:  0.999999332

p_ni:  6.29e-7

p_wrong:  3.9e-8

Score:  0.605

Data Source:  BioPlex,STRINGDB

OSCP1

Tbio

Novelty:  0.05361924

p_int:  0.999993651

p_ni:  0.000006329

p_wrong:  2.1e-8

Score:  0.816

Data Source:  BioPlex,STRINGDB

DACH2

Tbio

Novelty:  0.0806643

p_int:  0.999982445

p_ni:  0.000017553

p_wrong:  3e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

GYS1

Tchem

Family:  Enzyme

Novelty:  0.00721964

p_int:  0.999958277

p_ni:  0.000041723

Score:  0.996

Data Source:  BioPlex,STRINGDB

AMY2A

Tclin

Family:  Enzyme

Novelty:  0.00132709

p_int:  0.99993328

p_ni:  0.000028788

p_wrong:  0.000037932

Score:  0.172

Data Source:  BioPlex,STRINGDB

NONO

Tbio

Novelty:  0.00501502

p_int:  0.99989458

p_ni:  0.000105293

p_wrong:  1.27e-7

Score:  0.177

Data Source:  BioPlex,STRINGDB

GYG1

Tbio

Family:  Enzyme

Novelty:  0.01446978

p_int:  0.998748705

p_ni:  0.001251295

Score:  0.968

Data Source:  BioPlex,STRINGDB

SIRT5

Tchem

Family:  Epigenetic

Novelty:  0.00225239

p_int:  0.995233294

p_ni:  0.004766704

p_wrong:  2e-9

Score:  0.17

Data Source:  BioPlex,STRINGDB

RAE1

Tbio

Novelty:  0.01342883

p_int:  0.990452976

p_ni:  0.009547024

Score:  0.163

Data Source:  BioPlex,STRINGDB

SLC16A10

Tbio

Family:  Transporter

Novelty:  0.02363735

p_int:  0.98690382

p_ni:  0.012787982

p_wrong:  0.000308197

Score:  0.173

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (16)

Reactome (11)

KEGG (2)

UniProt (1)

WikiPathways (2)

Disease (R-HSA-1643685)

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Find Similar Targets

Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of carbohydrate metabolism	35 targets	R-HSA-5663084
Reactome	Diseases of metabolism	103 targets	R-HSA-5668914
Reactome	Glycogen breakdown (glycogenolysis)	15 targets	R-HSA-70221
Reactome	Glycogen metabolism	28 targets	R-HSA-8982491

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Diseases of carbohydrate metabolism	35 targets	R-HSA-5663084
Diseases of metabolism	103 targets	R-HSA-5668914
Glycogen breakdown (glycogenolysis)	15 targets	R-HSA-70221
Glycogen metabolism	28 targets	R-HSA-8982491

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
glycogenin glucosyltransferase activity	Inferred from Experiment (EXP)	Reactome
UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		81.8
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		77.1
body height	EFO_0004339	2	1	2		52.7
mean corpuscular volume	EFO_0004526	1	1	1		7.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		81.8
low density lipoprotein cholesterol measurement	EFO_0004611	1		77.1
body height	EFO_0004339	2		52.7
mean corpuscular volume	EFO_0004526	1		7.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Glycogen biosynthesis
Glycoprotein
Phosphoprotein
Polymorphism
Reference proteome
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
body height
low density lipoprotein cholesterol measurement
mean corpuscular volume
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glycogenin 2	VGNC:12391	465469
Macaque	glycogenin 2		720568
Dog	glycogenin 2	VGNC:41573	491717
Horse	glycogenin 2	VGNC:18669	100064536
Cow	glycogenin 2	VGNC:29729	505258

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glycogenin 2
Macaque	glycogenin 2
Dog	glycogenin 2
Horse	glycogenin 2
Cow	glycogenin 2

Publication Statistics

PubMed Score 69.05

PubMed score by year

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PubTator Score 37.45

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title