Protein Summary
Calcium-regulated non-lysosomal thiol-protease. Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]
- ENST00000278559
- ENSP00000278559
- ENSG00000149260
- ENST00000529629
- ENSP00000432332
- ENST00000531028
- ENSP00000467244
- ENST00000648180
- ENSP00000498132
- NCL3
- VRNI
- ADNIV
- HTRA3
- nCL-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
kinase perturbation | 0.81 | ||
disease perturbation | 0.79 | ||
histone modification site profile | 0.76 | ||
transcription factor binding site profile | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.08 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 229 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.08 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 229 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0