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Tbio
P4HA2
Prolyl 4-hydroxylase subunit alpha-2

Protein Summary
Description
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000166534
  • ENSP00000166534
  • ENSG00000072682
  • ENST00000360568
  • ENSP00000353772
  • ENST00000379086
  • ENSP00000368379
  • ENST00000379100
  • ENSP00000368394
  • ENST00000379104
  • ENSP00000368398
  • ENST00000401867
  • ENSP00000384999

Symbol
  • MYP25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.9
gene perturbation
0.88
molecular function
0.88
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.95   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.95   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
80.1
mosquito bite reaction itch intensity measurement
1
2
2
72.3
blood metabolite measurement
1
1
1
62.5
lifestyle measurement
1
1
1
56.1
1
1
0
1.3
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
80.1
mosquito bite reaction itch intensity measurement
2
72.3
blood metabolite measurement
1
62.5
lifestyle measurement
1
56.1
0
1.3
46.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolyl 4-hydroxylase subunit alpha 2
VGNC:7095
462047
Macaque
prolyl 4-hydroxylase subunit alpha 2
707157
Mouse
MGI:894286
18452
Rat
RGD:1309673
360526
Dog
prolyl 4-hydroxylase subunit alpha 2
VGNC:44223
474672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolyl 4-hydroxylase subunit alpha 2
Macaque
prolyl 4-hydroxylase subunit alpha 2
Mouse
Rat
Dog
prolyl 4-hydroxylase subunit alpha 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15460-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (168)
1 – 10 of 168
KIF7
Tbio
Novelty: 0.02734596
p_int: 0.999995604
p_ni: 0.000004395
p_wrong: 1e-9
Data Source: BioPlex
WDR33
Tbio
Novelty: 0.09221439
p_int: 0.999992585
p_ni: 0.000007415
Score: 0.172
Data Source: BioPlex,STRINGDB
TIGD5
Tdark
Novelty: 1.93340494
p_int: 0.999920565
p_ni: 0.000079404
p_wrong: 3.2e-8
Data Source: BioPlex
TSPYL4
Tdark
Novelty: 0.4538252
p_int: 0.999815351
p_ni: 0.000088654
p_wrong: 0.000095995
Data Source: BioPlex
KIAA1671
Tdark
Novelty: 1.1816849
p_int: 0.999552582
p_ni: 0.000447418
Data Source: BioPlex
COL14A1
Tbio
Novelty: 0.01760399
p_int: 0.999534581
p_ni: 0.000465419
Score: 0.907
Data Source: BioPlex,STRINGDB
FOXF2
Tbio
Family: TF
Novelty: 0.02032168
p_int: 0.999268643
p_ni: 0.000593269
p_wrong: 0.000138088
Score: 0.17
Data Source: BioPlex,STRINGDB
CPSF4
Tbio
Novelty: 0.00206207
p_int: 0.999185911
p_ni: 0.000814045
p_wrong: 4.4e-8
Score: 0.265
Data Source: BioPlex,STRINGDB
ZNF397
Tbio
Family: TF
Novelty: 0.60034816
p_int: 0.998934699
p_ni: 0.001059881
p_wrong: 0.00000542
Data Source: BioPlex
COL1A1
Tbio
Novelty: 0.00063584
p_int: 0.998842144
p_ni: 0.001157857
Score: 0.947
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  45.95

PubMed score by year
PubTator Score  10.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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