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Tbio
TLR3
Toll-like receptor 3

Protein Summary
Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundan ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296795
  • ENSP00000296795
  • ENSG00000164342
  • ENST00000504367
  • ENSP00000423684

Symbol
  • CD283
  • IIAE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
1
protein domain
0.85
histone modification site profile
0.82
biological term
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2146.85   (req: < 5)
Gene RIFs: 518   (req: <= 3)
Antibodies: 1071   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2146.85   (req: >= 5)
Gene RIFs: 518   (req: > 3)
Antibodies: 1071   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0