Tbio TLR3 Toll-like receptor 3

Protein Summary

Description

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15455
• B2RAI7
• B7Z7K0
• E6Y0F0
• E6Y0F1
• E9PGH4
• Q4VAL2
• Q504W0

Gene Name

• TLR3

Ensembl ID

• ENST00000296795
• ENSP00000296795
• ENSG00000164342
• ENST00000504367
• ENSP00000423684

Symbol

• CD283
• IIAE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
virus perturbation	1
protein domain	0.85
histone modification site profile	0.82
biological term	0.73

Protein Classes

PANTHER Classes

Protein / Receptor / Toll-like Receptor 3

Protein / Extracellular Matrix Protein / Toll-like Receptor 3

DTO Classes

Protein / Receptor / Toll-like Receptor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2146.85   (req: < 5)

Gene RIFs: 650   (req: <= 3)

Antibodies: 1071   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2146.85   (req: >= 5)

Gene RIFs: 650   (req: > 3)

Antibodies: 1071   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0