Tbio CD3EAP DNA-directed RNA polymerase I subunit RPA34

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.

Uniprot Accession IDs

• O15446
• Q32N11
• Q7Z5U2
• Q9UPF6

Gene Name

• CD3EAP

Ensembl ID

• ENST00000309424
• ENSP00000310966
• ENSG00000117877
• ENST00000589804
• ENSP00000465099

Symbol

• ASE1
• CAST
• PAF49
• ASE1
• CAST
• ASE-1
• PAF49

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.83
transcription factor binding site profile	0.83
histone modification site profile	0.82
cellular component	0.75
cell type or tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.83   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 278   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.83   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0