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Tbio
CCL25
C-C motif chemokine 25

Protein Summary
Description
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253451
  • ENSP00000253451
  • ENSG00000131142
  • ENST00000390669
  • ENSP00000375086

Symbol
  • SCYA25
  • TECK
  • TECK
  • Ckb15
  • SCYA25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.54
PubMedID
0.53
gene perturbation
0.48
biological process
0.46
molecular function
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.25   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.25   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CCL25 measurement
1
1
1
81.9
viral load
1
1
1
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CCL25 measurement
1
81.9
viral load
1
71.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 25
VGNC:11951
743059
Macaque
C-C motif chemokine ligand 25
574219
Mouse
MGI:1099448
20300
Rat
RGD:1305530
360750
Dog
C-C motif chemokine ligand 25
VGNC:38887
448798
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 25
Macaque
C-C motif chemokine ligand 25
Mouse
Rat
Dog
C-C motif chemokine ligand 25
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15444-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (282)
1 – 10 of 282
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999289856
p_ni:  0.000710139
p_wrong:  5e-9
Data Source:  BioPlex
SPATA20
Tdark
Novelty:  0.34126403
p_int:  0.934380829
p_ni:  0.065618887
p_wrong:  2.83e-7
Score:  0.26
Data Source:  BioPlex,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.757080835
p_ni:  0.242919165
Data Source:  BioPlex
CCR9
Tchem
Family:  GPCR
Novelty:  0.00654663
Score:  0.996
Data Source:  Reactome,STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.988
Data Source:  STRINGDB
CCL27
Tbio
Novelty:  0.00163457
Score:  0.976
Data Source:  STRINGDB
PF4
Tbio
Novelty:  0.00038481
Score:  0.973
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.971
Data Source:  STRINGDB
CCL19
Tbio
Novelty:  0.00169711
Score:  0.971
Data Source:  STRINGDB
ACKR4
Tbio
Family:  GPCR
Novelty:  0.00774541
Score:  0.97
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  118.25

PubMed score by year
PubTator Score  78.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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