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Tchem
ABCC5
Multidrug resistance-associated protein 5

Protein Summary
Description
Acts as a multispecific organic anion pump which can transport nucleotide analogs. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patie ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265586
  • ENSP00000265586
  • ENSG00000114770
  • ENST00000334444
  • ENSP00000333926
  • ENST00000382494
  • ENSP00000371934
  • ENST00000392579
  • ENSP00000376358
  • ENST00000443376
  • ENSP00000416840

Symbol
  • MRP5
  • MRP5
  • SMRP
  • ABC33
  • MOATC
  • MOAT-C
  • pABC11
  • EST277145
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.98
disease perturbation
0.95
transcription factor binding site profile
0.94
kinase perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.51   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.51   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sildenafil
Rendered image for sildenafil
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
90.9
mean platelet volume
2
2
2
83.7
neutrophil count
2
2
2
82
myeloid white cell count
1
1
1
73.6
leukocyte count
1
1
1
70.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
90.9
mean platelet volume
2
83.7
neutrophil count
2
82
myeloid white cell count
1
73.6
leukocyte count
1
70.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily C member 5
704326
Mouse
MGI:1351644
27416
Rat
RGD:70913
116721
Dog
ATP binding cassette subfamily C member 5
VGNC:37442
478648
Horse
ATP binding cassette subfamily C member 5
VGNC:14920
100066941
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily C member 5
Mouse
Rat
Dog
ATP binding cassette subfamily C member 5
Horse
ATP binding cassette subfamily C member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15440-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan biosynthesis and export
Reactome
Hyaluronan metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Glycosaminoglycan metabolism
Hyaluronan biosynthesis and export
Hyaluronan metabolism
Metabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (61)
1 – 10 of 61
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.999995049
p_ni:  0.000003107
p_wrong:  0.000001844
Score:  0.192
Data Source:  BioPlex,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.999756599
p_ni:  0.000022015
p_wrong:  0.000221386
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.999744971
p_ni:  0.000025685
p_wrong:  0.000229344
Score:  0.169
Data Source:  BioPlex,STRINGDB
ABCG4
Tbio
Family:  Transporter
Novelty:  0.02628545
Score:  0.847
Data Source:  STRINGDB
MRPS7
Tbio
Novelty:  0.00153134
Score:  0.81
Data Source:  STRINGDB
ABCF2
Tbio
Family:  Transporter
Novelty:  0.06782708
Score:  0.744
Data Source:  STRINGDB
ABCF1
Tbio
Family:  Transporter
Novelty:  0.03900964
Score:  0.624
Data Source:  STRINGDB
ABCG1
Tbio
Family:  Transporter
Novelty:  0.00213282
Score:  0.595
Data Source:  STRINGDB
SLC29A1
Tclin
Family:  Transporter
Novelty:  0.002085
Score:  0.584
Data Source:  STRINGDB
SLCO2B1
Tchem
Family:  Transporter
Novelty:  0.00517974
Score:  0.58
Data Source:  STRINGDB
Publication Statistics
PubMed Score  177.51

PubMed score by year
PubTator Score  122.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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