You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ABCC4
Multidrug resistance-associated protein 4

Protein Summary
Description
May be an organic anion pump relevant to cellular detoxification. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376887
  • ENSP00000366084
  • ENSG00000125257
  • ENST00000536256
  • ENSP00000442024
  • ENST00000629385
  • ENSP00000487081
  • ENST00000645237
  • ENSP00000494609
  • ENST00000646439
  • ENSP00000494751

Symbol
  • MRP4
  • MRP4
  • MOATB
  • MOAT-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.99
molecular function
0.99
chemical
0.96
trait
0.93
transcription factor binding site profile
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.96   (req: < 5)
Gene RIFs: 135   (req: <= 3)
Antibodies: 432   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.96   (req: >= 5)
Gene RIFs: 135   (req: > 3)
Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
estradiol disulfate
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
6
6
4.1
94.9
platelet crit
2
4
4
77.5
blood metabolite measurement
1
1
1
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
4.1
94.9
platelet crit
4
77.5
blood metabolite measurement
1
71.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 4
VGNC:13060
452625
Macaque
multidrug resistance-associated protein 4
695407
Mouse
MGI:2443111
239273
Rat
RGD:620266
170924
Dog
ATP binding cassette subfamily C member 4
VGNC:37441
485523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 4
Macaque
multidrug resistance-associated protein 4
Mouse
Rat
Dog
ATP binding cassette subfamily C member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15439-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (97)
1 – 10 of 97
PDZK1P1
Tdark
p_int: 0.999999912
p_ni: 8.1e-8
p_wrong: 8e-9
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999997166
p_ni: 0.000002834
Data Source: BioPlex
LRTM2
Tdark
Novelty: 1.14285986
p_int: 0.999994658
p_ni: 0.000005342
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999859477
p_ni: 0.000140523
Score: 0.523
Data Source: BioPlex,STRINGDB
NAT8B
Tbio
Family: Enzyme
p_int: 0.986811747
p_ni: 0.013142282
p_wrong: 0.000045971
Data Source: BioPlex
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.983918302
p_ni: 0.016081689
p_wrong: 9e-9
Score: 0.18
Data Source: BioPlex,STRINGDB
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.983863014
p_ni: 0.016129709
p_wrong: 0.000007277
Data Source: BioPlex
SLC4A8
Tbio
Family: Transporter
Novelty: 0.01606111
p_int: 0.983021239
p_ni: 0.016978741
p_wrong: 2e-8
Score: 0.234
Data Source: BioPlex,STRINGDB
REEP5
Tbio
Novelty: 0.00160455
p_int: 0.981567284
p_ni: 0.018432689
p_wrong: 2.8e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
TMEM128
Tdark
Novelty: 5.15874803
p_int: 0.967636288
p_ni: 0.032363709
p_wrong: 3e-9
Score: 0.527
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  455.96

PubMed score by year
PubTator Score  276.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: