You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC31A1
High affinity copper uptake protein 1

Protein Summary
Description
High-affinity, saturable copper transporter involved in dietary copper uptake. The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374212
  • ENSP00000363329
  • ENSG00000136868

Symbol
  • COPT1
  • CTR1
  • CTR1
  • COPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.89
transcription factor perturbation
0.88
cell type or tissue
0.79
transcription factor
0.7


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.46   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.46   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
7.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 31 member 1
VGNC:8934
464670
Macaque
solute carrier family 31 member 1
706058
Mouse
MGI:1333843
20529
Rat
RGD:620059
171135
Dog
solute carrier family 31 member 1
VGNC:51761
481678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 31 member 1
Macaque
solute carrier family 31 member 1
Mouse
Rat
Dog
solute carrier family 31 member 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15431-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Protein-Protein Interactions (76)
1 – 10 of 76
STX7
Tbio
Novelty: 0.03109969
p_int: 0.964121765
p_ni: 0.03587817
p_wrong: 6.4e-8
Score: 0.151
Data Source: BioPlex,STRINGDB
PLXDC2
Tbio
Novelty: 0.06496695
p_int: 0.951579816
p_ni: 0.048420184
Score: 0.177
Data Source: BioPlex,STRINGDB
CD70
Tbio
Novelty: 0.00420393
p_int: 0.949801851
p_ni: 0.050198004
p_wrong: 1.45e-7
Data Source: BioPlex
ERBB3
Tclin
Family: Kinase
Novelty: 0.000868
p_int: 0.932496876
p_ni: 0.067502664
p_wrong: 4.6e-7
Score: 0.234
Data Source: BioPlex,STRINGDB
TMPRSS11B
Tdark
Family: Enzyme
Novelty: 1.20690443
p_int: 0.896551143
p_ni: 0.103448731
p_wrong: 1.27e-7
Data Source: BioPlex
NCR3LG1
Tbio
Novelty: 0.02681936
p_int: 0.894228694
p_ni: 0.105771306
Score: 0.196
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.882102673
p_ni: 0.117897008
p_wrong: 3.2e-7
Data Source: BioPlex
CLEC2B
Tbio
Novelty: 0.06581244
p_int: 0.753779207
p_ni: 0.024224849
p_wrong: 0.221995943
Data Source: BioPlex
ATOX1
Tbio
Novelty: 0.00509938
Score: 0.876
Data Source: STRINGDB
ATP7A
Tbio
Family: Enzyme
Novelty: 0.00064155
Score: 0.865
Data Source: STRINGDB
Publication Statistics
PubMed Score  170.46

PubMed score by year
PubTator Score  198.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: