Tbio FOXP2 Forkhead box protein P2

Protein Summary

Description

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• O15409
• A0AUV6
• A4D0U8
• A6NNW4
• B4DLD9
• Q6ZND1
• Q75MJ3
• Q8IZE0
• Q8N0W2
• Q8N6B7
• Q8N6B8
• Q8NFQ1
• Q8NFQ2
• Q8NFQ3
• Q8NFQ4
• Q8TD74

Gene Name

• FOXP2

Ensembl ID

• ENST00000350908
• ENSP00000265436
• ENSG00000128573
• ENST00000360232
• ENSP00000353367
• ENST00000378237
• ENSP00000367482
• ENST00000393489
• ENSP00000377129
• ENST00000393494
• ENSP00000377132
• ENST00000403559
• ENSP00000385069
• ENST00000408937
• ENSP00000386200
• ENST00000412402
• ENSP00000405470
• ENST00000441290
• ENSP00000416825
• ENST00000635109
• ENSP00000489457

Symbol

• CAGH44
• TNRC10
• SPCH1
• CAGH44
• TNRC10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
molecular function	0.93
virus perturbation	0.85
biological process	0.83
transcription factor	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.16   (req: < 5)

Gene RIFs: 130   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.16   (req: >= 5)

Gene RIFs: 130   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0