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Tbio
FOXP2
Forkhead box protein P2

Protein Summary
Description
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350908
  • ENSP00000265436
  • ENSG00000128573
  • ENST00000360232
  • ENSP00000353367
  • ENST00000378237
  • ENSP00000367482
  • ENST00000393489
  • ENSP00000377129
  • ENST00000393494
  • ENSP00000377132
  • ENST00000403559
  • ENSP00000385069
  • ENST00000408937
  • ENSP00000386200
  • ENST00000412402
  • ENSP00000405470
  • ENST00000441290
  • ENSP00000416825
  • ENST00000635109
  • ENSP00000489457

Symbol
  • CAGH44
  • TNRC10
  • SPCH1
  • CAGH44
  • TNRC10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
molecular function
0.93
virus perturbation
0.85
biological process
0.83
transcription factor
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.67   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 433   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.67   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
FOXP1
Tbio
Family:  TF
Novelty:  0.00337994
p_int:  0.999999994
p_ni:  2e-9
p_wrong:  4e-9
Score:  0.689
Data Source:  BioPlex,STRINGDB
FOXP4
Tbio
Family:  TF
Novelty:  0.02668451
p_int:  0.999999975
p_ni:  5e-9
p_wrong:  2e-8
Score:  0.831
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999999352
p_ni:  6.48e-7
Data Source:  BioPlex
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
p_int:  0.999996603
p_ni:  8.69e-7
p_wrong:  0.000002528
Score:  0.846
Data Source:  BioPlex,STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
p_int:  0.999989263
p_ni:  0.000007689
p_wrong:  0.000003048
Score:  0.197
Data Source:  BioPlex,STRINGDB
EFHD1
Tbio
Novelty:  0.00808906
p_int:  0.998696978
p_ni:  0.000608608
p_wrong:  0.000694413
Score:  0.19
Data Source:  BioPlex,STRINGDB
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.990544017
p_ni:  0.009455762
p_wrong:  2.21e-7
Score:  0.174
Data Source:  BioPlex,STRINGDB
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.962839095
p_ni:  0.037160904
p_wrong:  1e-9
Score:  0.184
Data Source:  BioPlex,STRINGDB
PKP3
Tbio
Novelty:  0.0269462
p_int:  0.961355962
p_ni:  0.038643972
p_wrong:  6.7e-8
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.956743162
p_ni:  0.023631505
p_wrong:  0.019625333
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
4
5
6
1
95
age at first sexual intercourse measurement
1
2
2
85
1
1
1
83.5
insomnia measurement
2
3
0
1.1
82.9
sleep duration
2
3
2
1
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
6
1
95
age at first sexual intercourse measurement
2
85
1
83.5
insomnia measurement
0
1.1
82.9
sleep duration
2
1
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box P2
VGNC:4360
449627
Macaque
forkhead box P2
613237
Mouse
MGI:2148705
114142
Rat
RGD:1559697
500037
Dog
forkhead box P2
VGNC:40966
482413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box P2
Macaque
forkhead box P2
Mouse
Rat
Dog
forkhead box P2
Publication Statistics
PubMed Score 554.67
PubMed score by year
PubTator Score 253.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title