Tbio FOXP2 Forkhead box protein P2

Protein Summary

Description

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• O15409
• A0AUV6
• A4D0U8
• A6NNW4
• B4DLD9
• Q6ZND1
• Q75MJ3
• Q8IZE0
• Q8N0W2
• Q8N6B7
• Q8N6B8
• Q8NFQ1
• Q8NFQ2
• Q8NFQ3
• Q8NFQ4
• Q8TD74

Gene Name

• FOXP2

Ensembl ID

• ENST00000350908
• ENSP00000265436
• ENSG00000128573
• ENST00000360232
• ENSP00000353367
• ENST00000378237
• ENSP00000367482
• ENST00000393489
• ENSP00000377129
• ENST00000393494
• ENSP00000377132
• ENST00000403559
• ENSP00000385069
• ENST00000408937
• ENSP00000386200
• ENST00000412402
• ENSP00000405470
• ENST00000441290
• ENSP00000416825
• ENST00000635109
• ENSP00000489457

Symbol

• CAGH44
• TNRC10
• SPCH1
• CAGH44
• TNRC10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
molecular function	0.93
virus perturbation	0.85
biological process	0.83
transcription factor	0.79

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.33   (req: < 5)

Gene RIFs: 97   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.33   (req: >= 5)

Gene RIFs: 97   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (28)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 28

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
risk-taking behaviour	EFO_0008579	4	5	6	1	94.2
insomnia measurement	EFO_0007876	2	3	0	1.1	90.7
self reported educational attainment	EFO_0004784	3	4	4		88.8
Shoulder pain	HP_0030834	1	2	2		87.9
Neck pain	HP_0030833	1	2	2		87.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 28

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
risk-taking behaviour	EFO_0008579	6	1	94.2
insomnia measurement	EFO_0007876	0	1.1	90.7
self reported educational attainment	EFO_0004784	4		88.8
Shoulder pain	HP_0030834	2		87.9
Neck pain	HP_0030833	2		87.9

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	forkhead box P2	VGNC:4360	449627
Macaque	forkhead box P2		613237
Mouse	forkhead box P2	MGI:2148705	114142
Rat	forkhead box P2	RGD:1559697	500037
Dog	forkhead box P2	VGNC:40966	482413

Species	Name	OMA	EggNOG	Inparanoid
Chimp	forkhead box P2
Macaque	forkhead box P2
Mouse	forkhead box P2
Rat	forkhead box P2
Dog	forkhead box P2

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15409-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (1)

WikiPathways (1)

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Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Pathways Affected in Adenoid Cystic Carcinoma	565 targets	WP3651_r105781

Name	Explore in Pharos	Explore in Source
Pathways Affected in Adenoid Cystic Carcinoma	565 targets	WP3651_r105781

Gene Ontology Terms (28)

Functions (11)

Components (1)

Processes (16)

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10

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GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	BHF-UCL
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
androgen receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (113)

Explore Interacting Targets

1 – 10 of 113

• See Interactions on String-DB

FOXP1

Tbio

Family: TF

Novelty: 0.00337994

p_int: 0.999999994

p_ni: 2e-9

p_wrong: 4e-9

Score: 0.689

Data Source: BioPlex,STRINGDB

FOXP4

Tbio

Family: TF

Novelty: 0.02668451

p_int: 0.999999975

p_ni: 5e-9

p_wrong: 2e-8

Score: 0.831

Data Source: BioPlex,STRINGDB

MRPL12

Tbio

Novelty: 0.10646542

p_int: 0.999999352

p_ni: 6.48e-7

Data Source: BioPlex

FOXP3

Tbio

Family: TF

Novelty: 0.00017205

p_int: 0.999996603

p_ni: 8.69e-7

p_wrong: 0.000002528

Score: 0.846

Data Source: BioPlex,STRINGDB

HIST2H2AC

Tbio

Novelty: 0.00065524

p_int: 0.999989263

p_ni: 0.000007689

p_wrong: 0.000003048

Score: 0.197

Data Source: BioPlex,STRINGDB

EFHD1

Tbio

Novelty: 0.00808906

p_int: 0.998696978

p_ni: 0.000608608

p_wrong: 0.000694413

Score: 0.19

Data Source: BioPlex,STRINGDB

DUSP14

Tbio

Family: Enzyme

Novelty: 0.04013065

p_int: 0.990544017

p_ni: 0.009455762

p_wrong: 2.21e-7

Score: 0.174

Data Source: BioPlex,STRINGDB

SELENBP1

Tbio

Novelty: 0.00758018

p_int: 0.962839095

p_ni: 0.037160904

p_wrong: 1e-9

Score: 0.184

Data Source: BioPlex,STRINGDB

PKP3

Tbio

Novelty: 0.0269462

p_int: 0.961355962

p_ni: 0.038643972

p_wrong: 6.7e-8

Data Source: BioPlex

DSG4

Tbio

Novelty: 0.01599371

p_int: 0.956743162

p_ni: 0.023631505

p_wrong: 0.019625333

Data Source: BioPlex

Publication Statistics

PubMed Score  541.33

PubMed score by year

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PubTator Score  253.08

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Chromosomal rearrangement
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Disease mutation
DNA-binding
Metal-binding
Nucleus
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Repressor

GWAS Trait Find Similar Targets

age at first birth measurement
attention deficit hyperactivity disorder
body height
body mass index
Cannabis use
childhood trauma measurement
chronotype measurement
diabetes mellitus
diet measurement
feeling tense measurement

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype