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Tbio
FOXP2
Forkhead box protein P2

Protein Summary
Description
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350908
  • ENSP00000265436
  • ENSG00000128573
  • ENST00000360232
  • ENSP00000353367
  • ENST00000378237
  • ENSP00000367482
  • ENST00000393489
  • ENSP00000377129
  • ENST00000393494
  • ENSP00000377132
  • ENST00000403559
  • ENSP00000385069
  • ENST00000408937
  • ENSP00000386200
  • ENST00000412402
  • ENSP00000405470
  • ENST00000441290
  • ENSP00000416825
  • ENST00000635109
  • ENSP00000489457

Symbol
  • CAGH44
  • TNRC10
  • SPCH1
  • CAGH44
  • TNRC10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
molecular function
0.93
virus perturbation
0.85
biological process
0.83
transcription factor
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.33   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 433   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.33   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
4
5
6
1
94.2
insomnia measurement
2
3
0
1.1
90.7
self reported educational attainment
3
4
4
88.8
Shoulder pain
1
2
2
87.9
Neck pain
1
2
2
87.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
6
1
94.2
insomnia measurement
0
1.1
90.7
self reported educational attainment
4
88.8
Shoulder pain
2
87.9
Neck pain
2
87.9
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (113)
1 – 10 of 113
FOXP1
Tbio
Family: TF
Novelty: 0.00337994
p_int: 0.999999994
p_ni: 2e-9
p_wrong: 4e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
FOXP4
Tbio
Family: TF
Novelty: 0.02668451
p_int: 0.999999975
p_ni: 5e-9
p_wrong: 2e-8
Score: 0.831
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.999999352
p_ni: 6.48e-7
Data Source: BioPlex
FOXP3
Tbio
Family: TF
Novelty: 0.00017205
p_int: 0.999996603
p_ni: 8.69e-7
p_wrong: 0.000002528
Score: 0.846
Data Source: BioPlex,STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
p_int: 0.999989263
p_ni: 0.000007689
p_wrong: 0.000003048
Score: 0.197
Data Source: BioPlex,STRINGDB
EFHD1
Tbio
Novelty: 0.00808906
p_int: 0.998696978
p_ni: 0.000608608
p_wrong: 0.000694413
Score: 0.19
Data Source: BioPlex,STRINGDB
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.990544017
p_ni: 0.009455762
p_wrong: 2.21e-7
Score: 0.174
Data Source: BioPlex,STRINGDB
SELENBP1
Tbio
Novelty: 0.00758018
p_int: 0.962839095
p_ni: 0.037160904
p_wrong: 1e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
PKP3
Tbio
Novelty: 0.0269462
p_int: 0.961355962
p_ni: 0.038643972
p_wrong: 6.7e-8
Data Source: BioPlex
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.956743162
p_ni: 0.023631505
p_wrong: 0.019625333
Data Source: BioPlex
Publication Statistics
PubMed Score  541.33

PubMed score by year
PubTator Score  253.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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