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Tbio
TOX3
TOX high mobility group box family member 3

Protein Summary
Description
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219746
  • ENSP00000219746
  • ENSG00000103460
  • ENST00000407228
  • ENSP00000385705

Symbol
  • CAGF9
  • TNRC9
  • CAGF9
  • TNRC9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
PubMedID
0.88
gene perturbation
0.82
transcription factor perturbation
0.74
biological process
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.77   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.77   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
LSP1
Tbio
Novelty:  0.00889927
Score:  0.84
Data Source:  STRINGDB
MAP2K5
Tchem
Family:  Kinase
Novelty:  0.00587774
Score:  0.776
Data Source:  STRINGDB
MAP3K1
Tchem
Family:  Kinase
Novelty:  0.0041131
Score:  0.766
Data Source:  STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
Score:  0.753
Data Source:  STRINGDB
SKOR1
Tbio
Novelty:  0.07579796
Score:  0.712
Data Source:  STRINGDB
BTBD9
Tbio
Novelty:  0.02793632
Score:  0.686
Data Source:  STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
Score:  0.684
Data Source:  STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
Score:  0.682
Data Source:  STRINGDB
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
Score:  0.68
Data Source:  STRINGDB
RAD51B
Tbio
Novelty:  0.00302521
Score:  0.677
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Regulation of toll-like receptor signaling pathway
WikiPathways
Ectoderm Differentiation
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Regulation of toll-like receptor signaling pathway
Ectoderm Differentiation
Endoderm Differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
17
5
0
1.2
98.8
2
2
0
1.3
95.5
2
1
0
1.1
77.7
hematocrit
2
2
2
73.4
1
1
0
1.5
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.8
0
1.3
95.5
0
1.1
77.7
hematocrit
2
73.4
0
1.5
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TOX high mobility group box family member 3
VGNC:9117
454084
Macaque
TOX high mobility group box family member 3
696002
Mouse
MGI:3039593
244579
Rat
RGD:1311529
291908
Dog
TOX high mobility group box family member 3
487281
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TOX high mobility group box family member 3
Macaque
TOX high mobility group box family member 3
Mouse
Rat
Dog
TOX high mobility group box family member 3
Publication Statistics
PubMed Score 77.77
PubMed score by year
PubTator Score 57.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title