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Tbio
STX7
Syntaxin-7

Protein Summary
Description
May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367937
  • ENSP00000356914
  • ENSG00000079950
  • ENST00000367941
  • ENSP00000356918
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
cell type or tissue
0.83
transcription factor perturbation
0.8
interacting protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.68   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.68   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
81.8
reticulocyte count
6
2
6
65.4
reticulocyte measurement
3
1
3
11.2
mean corpuscular volume
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
81.8
reticulocyte count
6
65.4
reticulocyte measurement
3
11.2
mean corpuscular volume
1
2.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 7
VGNC:3714
463004
Macaque
syntaxin 7
709667
Mouse
MGI:1858210
53331
Rat
RGD:619747
60466
Dog
syntaxin 7
VGNC:46958
483987
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 7
Macaque
syntaxin 7
Mouse
Rat
Dog
syntaxin 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15400-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (31)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (175)
1 – 10 of 175
NAPG
Tbio
Novelty: 0.02295985
p_int: 0.999999996
p_ni: 4e-9
Score: 0.889
Data Source: BioPlex,STRINGDB
STX6
Tbio
Novelty: 0.01494028
p_int: 0.999999949
p_ni: 5.1e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
VAMP4
Tbio
Novelty: 0.02949854
p_int: 0.999999916
p_ni: 8.4e-8
Score: 0.956
Data Source: BioPlex,STRINGDB
STXBP5
Tbio
Novelty: 0.01899802
p_int: 0.999999839
p_ni: 1.61e-7
Score: 0.808
Data Source: BioPlex,STRINGDB
GOSR1
Tbio
Novelty: 0.03139481
p_int: 0.999999379
p_ni: 6.21e-7
Score: 0.93
Data Source: BioPlex,STRINGDB
VTI1B
Tbio
Novelty: 0.00955467
p_int: 0.999999148
p_ni: 8.52e-7
Score: 0.988
Data Source: BioPlex,STRINGDB
STXBP6
Tbio
Novelty: 0.13195671
p_int: 0.999996561
p_ni: 0.000003439
p_wrong: 1e-9
Score: 0.746
Data Source: BioPlex,STRINGDB
ZKSCAN1
Tbio
Family: TF
Novelty: 0.08190662
p_int: 0.999993234
p_ni: 0.000006765
p_wrong: 1e-9
Score: 0.224
Data Source: BioPlex,STRINGDB
VTI1A
Tbio
Novelty: 0.04616617
p_int: 0.999988421
p_ni: 0.000011437
p_wrong: 1.42e-7
Score: 0.991
Data Source: BioPlex,STRINGDB
GOSR2
Tbio
Novelty: 0.02447711
p_int: 0.99998756
p_ni: 0.000012439
Score: 0.904
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.68

PubMed score by year
PubTator Score  20

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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