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Tclin
GRIN2D
Glutamate receptor ionotropic, NMDA 2D

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750). N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), N ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263269
  • ENSP00000263269
  • ENSG00000105464

Symbol
  • GluN2D
  • NMDAR2D
  • EB11
  • NR2D
  • EIEE46
  • GluN2D
  • NMDAR2D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.92
molecular function
0.86
hub protein
0.75
protein domain
0.73
drug
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.33   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.33   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Pathways (77)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
FLT3 Signaling
Protein-Protein Interactions (119)
1 – 10 of 119
GRIN1
Tclin
Family: IC
Novelty: 0.00132693
Score: 0.975
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00079421
Score: 0.975
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.00904059
Score: 0.959
Data Source: Reactome,STRINGDB
DLG2
Tbio
Novelty: 0.01593948
Score: 0.957
Data Source: Reactome,STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.00063312
Score: 0.94
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00363124
Score: 0.937
Data Source: STRINGDB
CAMK2G
Tchem
Family: Kinase
Novelty: 0.08749205
Score: 0.936
Data Source: STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.01196206
Score: 0.933
Data Source: STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0055702
Score: 0.933
Data Source: STRINGDB
GRIA3
Tclin
Family: IC
Novelty: 0.00921177
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  136.33

PubMed score by year
PubTator Score  56.37

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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