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Tclin
GRIN2D
Glutamate receptor ionotropic, NMDA 2D

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750). N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), N ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263269
  • ENSP00000263269
  • ENSG00000105464

Symbol
  • GluN2D
  • NMDAR2D
  • EB11
  • NR2D
  • EIEE46
  • GluN2D
  • NMDAR2D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.92
molecular function
0.86
hub protein
0.75
protein domain
0.73
drug
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.53   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.53   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (9)
1 – 9 of 9
DQP-1105
Rendered image for DQP-1105
CHEMBL4435232
Rendered image for CHEMBL4435232
CHEMBL2333944
Rendered image for CHEMBL2333944
CHEMBL4447266
Rendered image for CHEMBL4447266
CHEMBL2397100
Rendered image for CHEMBL2397100
CHEMBL1215292
Rendered image for CHEMBL1215292
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
31.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glutamate ionotropic receptor NMDA type subunit 2D
717945
Mouse
MGI:95823
14814
Rat
RGD:2740
24412
Dog
glutamate ionotropic receptor NMDA type subunit 2D
VGNC:41495
484405
Pig
glutamate ionotropic receptor NMDA type subunit 2D
100521797
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glutamate ionotropic receptor NMDA type subunit 2D
Mouse
Rat
Dog
glutamate ionotropic receptor NMDA type subunit 2D
Pig
glutamate ionotropic receptor NMDA type subunit 2D
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15399-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (77)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
FLT3 Signaling
Protein-Protein Interactions (119)
1 – 10 of 119
GRIN1
Tclin
Family:  IC
Novelty:  0.0011807
Score:  0.975
Data Source:  Reactome,STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.975
Data Source:  Reactome,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
Score:  0.959
Data Source:  Reactome,STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.957
Data Source:  Reactome,STRINGDB
GRIA1
Tclin
Family:  IC
Novelty:  0.0005008
Score:  0.94
Data Source:  STRINGDB
GRIA4
Tclin
Family:  IC
Novelty:  0.00284417
Score:  0.937
Data Source:  STRINGDB
CAMK2G
Tchem
Family:  Kinase
Novelty:  0.04642387
Score:  0.936
Data Source:  STRINGDB
CAMK2A
Tchem
Family:  Kinase
Novelty:  0.00534906
Score:  0.933
Data Source:  STRINGDB
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
Score:  0.933
Data Source:  STRINGDB
GRIA3
Tclin
Family:  IC
Novelty:  0.00584546
Score:  0.933
Data Source:  STRINGDB
Publication Statistics
PubMed Score  192.53

PubMed score by year
PubTator Score  56.37

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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