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Tbio
IPO8
Importin-8

Protein Summary
Description
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256079
  • ENSP00000256079
  • ENSG00000133704
  • ENST00000544829
  • ENSP00000444520

Symbol
  • RANBP8
  • RANBP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.8
transcription factor perturbation
0.8
interacting protein
0.76
cell line
0.75
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.39   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.39   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
88.1
monocyte count
1
1
1
68.8
lifestyle measurement
1
1
1
56.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
88.1
monocyte count
1
68.8
lifestyle measurement
1
56.1
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
Transcriptional regulation by small RNAs
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
Transcriptional regulation by small RNAs
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (176)
1 – 10 of 176
ZNF331
Tbio
Family: TF
Novelty: 0.05976217
p_int: 0.999809407
p_ni: 0.000190593
Score: 0.432
Data Source: BioPlex,STRINGDB
ZSCAN5A
Tdark
Family: TF
Novelty: 2.15267128
p_int: 0.999542133
p_ni: 0.000457867
Score: 0.227
Data Source: BioPlex,STRINGDB
SIGLECL1
Tdark
p_int: 0.986910937
p_ni: 0.013089063
Data Source: BioPlex
TNFSF13B
Tclin
Novelty: 0.00069885
p_int: 0.965540109
p_ni: 0.034459891
Data Source: BioPlex
GALNT16
Tbio
Family: Enzyme
Novelty: 0.34686672
p_int: 0.965270414
p_ni: 0.034729586
Score: 0.189
Data Source: BioPlex,STRINGDB
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.895416335
p_ni: 0.104583665
Data Source: BioPlex
ZNF287
Tdark
Family: TF
Novelty: 1.01445884
p_int: 0.888455222
p_ni: 0.111544778
Data Source: BioPlex
BSG
Tbio
Novelty: 0.0010285
p_int: 0.871290073
p_ni: 0.128709927
Data Source: BioPlex
HP1BP3
Tbio
Novelty: 0.07014109
p_int: 0.870926819
p_ni: 0.129073181
Data Source: BioPlex
ZSCAN21
Tbio
Family: TF
Novelty: 0.18025344
p_int: 0.835783784
p_ni: 0.164216216
Data Source: BioPlex
Publication Statistics
PubMed Score  98.39

PubMed score by year
PubTator Score  29.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer