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Tchem
TMPRSS2
Transmembrane protease serine 2

Protein Summary
Description
Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); invol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332149
  • ENSP00000330330
  • ENSG00000184012
  • ENST00000398585
  • ENSP00000381588
  • ENST00000458356
  • ENSP00000391216

Symbol
  • PRSS10
  • PP9284
  • PRSS10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.9
biological term
0.86
disease perturbation
0.83
gene perturbation
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 915.67   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 915.67   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
3
3
0
1.1
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
73.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 2
VGNC:3729
474007
Macaque
transmembrane protease, serine 2
715138
Mouse
MGI:1354381
50528
Rat
RGD:620766
156435
Dog
transmembrane serine protease 2
VGNC:53045
487770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 2
Macaque
transmembrane protease, serine 2
Mouse
Rat
Dog
transmembrane serine protease 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15393-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Prostate cancer
KEGG
Transcriptional misregulation in cancer
KEGG
Influenza A
Name
Explore in Pharos
Explore in Source
Prostate cancer
Transcriptional misregulation in cancer
Influenza A
Protein-Protein Interactions (78)
1 – 10 of 78
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.94
Data Source: STRINGDB
NKX3-1
Tbio
Family: TF
Novelty: 0.00496721
Score: 0.856
Data Source: STRINGDB
TMPRSS4
Tbio
Family: Enzyme
Novelty: 0.01429547
Score: 0.851
Data Source: STRINGDB
ETV1
Tbio
Family: TF
Novelty: 0.0055085
Score: 0.803
Data Source: STRINGDB
SLC45A3
Tbio
Family: Transporter
Novelty: 0.0178929
Score: 0.774
Data Source: STRINGDB
ERG
Tbio
Family: TF
Novelty: 0.04049734
Score: 0.726
Data Source: STRINGDB
ETV4
Tbio
Family: TF
Novelty: 0.00317361
Score: 0.726
Data Source: STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
Score: 0.717
Data Source: STRINGDB
FAM3B
Tbio
Novelty: 0.00844967
Score: 0.706
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.69
Data Source: STRINGDB
Publication Statistics
PubMed Score  915.67

PubMed score by year
PubTator Score  464.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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