You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
BIRC5
Baculoviral IAP repeat-containing protein 5

Protein Summary
Description
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a defaul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374948
  • ENSP00000364086
  • ENSG00000089685
  • ENST00000590449
  • ENSP00000465868
  • ENST00000590925
  • ENSP00000467336
  • ENST00000592734
  • ENSP00000466617

Symbol
  • API4
  • IAP4
  • API4
  • EPR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
co-expressed gene
0.95
kinase perturbation
0.95
transcription factor perturbation
0.94
biological term
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.91   (req: < 5)
Gene RIFs: 1093   (req: <= 3)
Antibodies: 1598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.91   (req: >= 5)
Gene RIFs: 1093   (req: > 3)
Antibodies: 1598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0