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Tbio
SIGLEC5
Sialic acid-binding Ig-like lectin 5

Protein Classes
Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000534261
  • ENSP00000473238
  • ENSG00000105501

Symbol
  • CD33L2
  • OBBP2
  • CD170
  • OBBP2
  • CD33L2
  • OB-BP2
  • SIGLEC-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
protein domain
0.85
tissue sample
0.84
tissue
0.61
cell line
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.37   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 527   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.37   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 527   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
3
76.7
eosinophil count
1
1
1
69.5
neutrophil percentage of leukocytes
1
1
1
59.5
eosinophil percentage of leukocytes
1
1
1
56.4
mean corpuscular volume
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
76.7
eosinophil count
1
69.5
neutrophil percentage of leukocytes
1
59.5
eosinophil percentage of leukocytes
1
56.4
mean corpuscular volume
1
38.8
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sialic acid binding Ig like lectin 5
719730
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sialic acid binding Ig like lectin 5
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15389-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
p_int:  0.999825762
p_ni:  0.000174238
Score:  0.627
Data Source:  BioPlex,STRINGDB
PHOSPHO2
Tdark
Family:  Enzyme
Novelty:  0.36911271
p_int:  0.998491407
p_ni:  0.001487957
p_wrong:  0.000020636
Score:  0.309
Data Source:  BioPlex,STRINGDB
KLHL8
Tdark
Novelty:  0.4838314
p_int:  0.991371597
p_ni:  0.00619742
p_wrong:  0.002430983
Data Source:  BioPlex
TRIP10
Tbio
Novelty:  0.01553463
p_int:  0.970499611
p_ni:  0.029500389
Score:  0.197
Data Source:  BioPlex,STRINGDB
INTS4
Tdark
Novelty:  0.20868831
p_int:  0.884187601
p_ni:  0.115812399
Score:  0.173
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.867729145
p_ni:  0.132270841
p_wrong:  1.4e-8
Data Source:  BioPlex
METTL13
Tbio
Family:  Enzyme
Novelty:  0.15986409
p_int:  0.833412358
p_ni:  0.166587642
Score:  0.228
Data Source:  BioPlex,STRINGDB
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.771778789
p_ni:  0.228221211
Score:  0.179
Data Source:  BioPlex,STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.602
Data Source:  STRINGDB
SLAMF1
Tbio
Novelty:  0.00112892
Score:  0.575
Data Source:  STRINGDB
Publication Statistics
PubMed Score  57.37

PubMed score by year
PubTator Score  29.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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