Tchem BCAT2 Branched-chain-amino-acid aminotransferase, mitochondrial

Protein Classes

PANTHER Classes

Protein / Transferase / Transaminase / Branched-chain-amino-acid Aminotransferase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Transaminase / Branched-chain-amino-acid Aminotransferase, Mitochondrial

Protein Summary

Description

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• O15382
• B2RB87
• O00269
• Q96KG1
• Q9BTB6
• Q9BUU6
• BCAT(m)

Gene Name

• BCAT2

Ensembl ID

• ENST00000316273
• ENSP00000322991
• ENSG00000105552
• ENST00000545387
• ENSP00000440973

Symbol

• BCATM
• BCT2
• ECA40
• BCAM
• BCT2
• PP18
• BCATM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.88
histone modification site profile	0.84
transcription factor	0.77
PubMedID	0.76
co-expressed gene	0.72

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.57   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 245   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.57   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (47)

Explore Active Ligands

1 – 10 of 47

CHEMBL3617078

BCAT2Tchem Enzyme

IC50 : 7.3

CHEMBL3617085

BCAT2Tchem Enzyme

IC50 : 7.8

CHEMBL3809820

BCAT2Tchem Enzyme

IC50 : 6

CHEMBL3617108

BCAT2Tchem Enzyme

IC50 : 6

CHEMBL3617103

BCAT2Tchem Enzyme

IC50 : 6.6

CHEMBL3617071

BCAT2Tchem Enzyme

IC50 : 6.7

CHEMBL3794532

BCAT2Tchem Enzyme

IC50 : 6

CHEMBL3617087

BCAT2Tchem Enzyme

IC50 : 6.1

CHEMBL3617092

BCAT2Tchem Enzyme

IC50 : 6.2

CHEMBL3808530

BCAT2Tchem Enzyme

IC50 : 6.1

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	branched chain amino acid transaminase 2	VGNC:8611	456189
Macaque	branched chain amino acid transaminase 2		718305
Mouse	branched chain aminotransferase 2, mitochondrial	MGI:1276534	12036
Rat	branched chain amino acid transaminase 2	RGD:68948	64203
Dog	branched chain amino acid transaminase 2	VGNC:38402	484394

Species	Name	OMA	EggNOG	Inparanoid
Chimp	branched chain amino acid transaminase 2
Macaque	branched chain amino acid transaminase 2
Mouse	branched chain aminotransferase 2, mitochondrial
Rat	branched chain amino acid transaminase 2
Dog	branched chain amino acid transaminase 2

Protein Structure (28 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15382-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 28

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (21)

Reactome (3)

KEGG (7)

PathwayCommons (7)

WikiPathways (4)

Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Branched-chain amino acid catabolism	19 targets	R-HSA-70895
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291

Name	Explore in Pharos	Explore in Source
Branched-chain amino acid catabolism	19 targets	R-HSA-70895
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291

Gene Ontology Terms (13)

Functions (4)

Components (2)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
branched-chain-amino-acid transaminase activity	Inferred from Experiment (EXP)	Reactome
L-isoleucine transaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
L-leucine transaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
L-valine transaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Protein-Protein Interactions (95)

Explore Interacting Targets

1 – 10 of 95

• See Interactions on String-DB

YBEY

Tdark

Family: Enzyme

Novelty: 0.02778029

p_int: 0.999931925

p_ni: 0.000066971

p_wrong: 0.000001104

Score: 0.348

Data Source: BioPlex,STRINGDB

EEF2KMT

Tdark

Family: Enzyme

Novelty: 0.33892681

p_int: 0.999885879

p_ni: 0.000114118

p_wrong: 3e-9

Score: 0.548

Data Source: BioPlex,STRINGDB

NDUFS6

Tclin

Family: Enzyme

Novelty: 0.07910252

p_int: 0.995429847

p_ni: 0.004568907

p_wrong: 0.000001246

Score: 0.205

Data Source: BioPlex,STRINGDB

HSPD1

Tbio

Novelty: 0.00018924

p_int: 0.992040477

p_ni: 0.007959523

Score: 0.25

Data Source: BioPlex,STRINGDB

NIT1

Tbio

Family: Enzyme

Novelty: 0.00498587

p_int: 0.788540861

p_ni: 0.211458831

p_wrong: 3.08e-7

Score: 0.242

Data Source: BioPlex,STRINGDB

BCKDHB

Tbio

Family: Enzyme

Novelty: 0.02234969

Score: 0.972

Data Source: STRINGDB

BCKDHA

Tbio

Family: Enzyme

Novelty: 0.01684893

Score: 0.966

Data Source: STRINGDB

DBT

Tbio

Family: Enzyme

Novelty: 0.0070589

Score: 0.963

Data Source: STRINGDB

DLD

Tbio

Family: Enzyme

Novelty: 0.00214298

Score: 0.955

Data Source: STRINGDB

CTH

Tchem

Family: Enzyme

Novelty: 0.0017155

Score: 0.946

Data Source: STRINGDB

Publication Statistics

PubMed Score  111.57

PubMed score by year

Reset Zoom

PubTator Score  34.62

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Amino-acid biosynthesis
Aminotransferase
Branched-chain amino acid biosynthesis
Complete proteome
Cytoplasm
Mitochondrion
Polymorphism

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
renal/urinary system phenotype