BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial
Protein Summary
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- ENST00000316273
- ENSP00000322991
- ENSG00000105552
- ENST00000545387
- ENSP00000440973
- BCATM
- BCT2
- ECA40
- BCAM
- BCT2
- PP18
- BCATM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.84 | ||
transcription factor | 0.77 | ||
PubMedID | 0.76 | ||
co-expressed gene | 0.72 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.78 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 245 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.78 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 245 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 47
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (47)
1 – 10 of 47
Protein-Protein Interactions (95)
1 – 10 of 95
YBEY
Family: Enzyme
Novelty: 0.02778029
p_int: 0.999931925
p_ni: 0.000066971
p_wrong: 0.000001104
Score: 0.348
Data Source: BioPlex,STRINGDB
EEF2KMT
Family: Enzyme
Novelty: 0.33892681
p_int: 0.999885879
p_ni: 0.000114118
p_wrong: 3e-9
Score: 0.548
Data Source: BioPlex,STRINGDB
NDUFS6
Family: Enzyme
Novelty: 0.07910252
p_int: 0.995429847
p_ni: 0.004568907
p_wrong: 0.000001246
Score: 0.205
Data Source: BioPlex,STRINGDB
HSPD1
Novelty: 0.00018924
p_int: 0.992040477
p_ni: 0.007959523
Score: 0.25
Data Source: BioPlex,STRINGDB
NIT1
Family: Enzyme
Novelty: 0.00498587
p_int: 0.788540861
p_ni: 0.211458831
p_wrong: 3.08e-7
Score: 0.242
Data Source: BioPlex,STRINGDB
BCKDHB
Family: Enzyme
Novelty: 0.02234969
Score: 0.972
Data Source: STRINGDB
BCKDHA
Family: Enzyme
Novelty: 0.01684893
Score: 0.966
Data Source: STRINGDB
DBT
Family: Enzyme
Novelty: 0.0070589
Score: 0.963
Data Source: STRINGDB
DLD
Family: Enzyme
Novelty: 0.00214298
Score: 0.955
Data Source: STRINGDB
CTH
Family: Enzyme
Novelty: 0.0017155
Score: 0.946
Data Source: STRINGDB
Pathways (21)
Reactome (3)
KEGG (7)
PathwayCommons (7)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Branched-chain amino acid catabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Branched-chain amino acid catabolism | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Gene Ontology Terms (13)
Functions (4)
Components (2)
Processes (7)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
GWAS Traits (78)
Items per page:
1 – 5 of 78
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 3 | 8 | 7 | 2.3 | 99.3 | ||||
alkaline phosphatase measurement | 3 | 5 | 4 | 1.8 | 99.1 | ||||
low density lipoprotein cholesterol measurement | 5 | 10 | 14 | 98.6 | |||||
apolipoprotein B measurement | 2 | 5 | 5 | 97 | |||||
reticulocyte measurement | 3 | 5 | 6 | 96.1 | |||||
Items per page:
1 – 5 of 78
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 7 | 2.3 | 99.3 | ||||
alkaline phosphatase measurement | 4 | 1.8 | 99.1 | ||||
low density lipoprotein cholesterol measurement | 14 | 98.6 | |||||
apolipoprotein B measurement | 5 | 97 | |||||
reticulocyte measurement | 6 | 96.1 | |||||
Find similar targets by:
UniProt Keyword
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GWAS Trait
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Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | branched chain amino acid transaminase 2 | VGNC:8611 | 456189 | |||||
Macaque | branched chain amino acid transaminase 2 | 718305 | ||||||
Mouse | MGI:1276534 | 12036 | ||||||
Rat | RGD:68948 | 64203 | ||||||
Dog | branched chain amino acid transaminase 2 | VGNC:38402 | 484394 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | branched chain amino acid transaminase 2 | |||||
Macaque | branched chain amino acid transaminase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | branched chain amino acid transaminase 2 | |||||
Publication Statistics
PubMed Score 115.78
PubMed score by year
PubTator Score 34.62
PubTator score by year