Tchem BCAT2 Branched-chain-amino-acid aminotransferase, mitochondrial

Protein Classes

PANTHER Classes

Protein / Transferase / Transaminase / Branched-chain-amino-acid Aminotransferase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Transaminase / Branched-chain-amino-acid Aminotransferase, Mitochondrial

Protein Summary

Description

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• O15382
• B2RB87
• O00269
• Q96KG1
• Q9BTB6
• Q9BUU6
• BCAT(m)

Gene Name

• BCAT2

Ensembl ID

• ENST00000316273
• ENSP00000322991
• ENSG00000105552
• ENST00000545387
• ENSP00000440973

Symbol

• BCATM
• BCT2
• ECA40
• BCAM
• BCT2
• PP18
• BCATM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.88
histone modification site profile	0.84
transcription factor	0.77
PubMedID	0.76
co-expressed gene	0.72

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.57   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 245   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.57   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (47)

Explore Active Ligands

1 – 10 of 47

CHEMBL3617078

BCAT2Tchem Enzyme

IC50: 7.3

CHEMBL3617085

BCAT2Tchem Enzyme

IC50: 7.8

CHEMBL3617103

BCAT2Tchem Enzyme

IC50: 6.6

CHEMBL3617071

BCAT2Tchem Enzyme

IC50: 6.7

CHEMBL3617092

BCAT2Tchem Enzyme

IC50: 6.2

CHEMBL3617100

BCAT2Tchem Enzyme

IC50: 6.9

CHEMBL3617094

BCAT2Tchem Enzyme

IC50: 7.1

CHEMBL3808971

BCAT2Tchem Enzyme

IC50: 7.2

CHEMBL3617077

BCAT2Tchem Enzyme

IC50: 7.3

CHEMBL3617095

BCAT2Tchem Enzyme

IC50: 7.6

Protein Data Bank (28)

1 – 5 of 28

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (21)

Reactome (3)

KEGG (7)

PathwayCommons (7)

WikiPathways (4)

Branched-chain amino acid catabolism (R-HSA-70895)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Branched-chain amino acid catabolism	19 targets	R-HSA-70895
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291

Name	Explore in Pharos	Explore in Source
Branched-chain amino acid catabolism	19 targets	R-HSA-70895
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291

Gene Ontology Terms (13)

Functions (4)

Components (2)

Processes (7)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
branched-chain-amino-acid transaminase activity	Inferred from Experiment (EXP)	Reactome
L-isoleucine transaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
L-leucine transaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
L-valine transaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Protein-Protein Interactions (95)

Explore Interacting Targets

1 – 10 of 95

• See Interactions on String-DB

YBEY

Tdark

Family: Enzyme

Novelty: 0.02778029

p_int: 0.999931925

p_ni: 0.000066971

p_wrong: 0.000001104

Score: 0.348

Data Source: BioPlex,STRINGDB

EEF2KMT

Tdark

Family: Enzyme

Novelty: 0.33892681

p_int: 0.999885879

p_ni: 0.000114118

p_wrong: 3e-9

Score: 0.548

Data Source: BioPlex,STRINGDB

NDUFS6

Tclin

Family: Enzyme

Novelty: 0.07910252

p_int: 0.995429847

p_ni: 0.004568907

p_wrong: 0.000001246

Score: 0.205

Data Source: BioPlex,STRINGDB

HSPD1

Tbio

Novelty: 0.00018924

p_int: 0.992040477

p_ni: 0.007959523

Score: 0.25

Data Source: BioPlex,STRINGDB

NIT1

Tbio

Family: Enzyme

Novelty: 0.00498587

p_int: 0.788540861

p_ni: 0.211458831

p_wrong: 3.08e-7

Score: 0.242

Data Source: BioPlex,STRINGDB

BCKDHB

Tbio

Family: Enzyme

Novelty: 0.02234969

Score: 0.972

Data Source: STRINGDB

BCKDHA

Tbio

Family: Enzyme

Novelty: 0.01684893

Score: 0.966

Data Source: STRINGDB

DBT

Tbio

Family: Enzyme

Novelty: 0.0070589

Score: 0.963

Data Source: STRINGDB

DLD

Tbio

Family: Enzyme

Novelty: 0.00214298

Score: 0.955

Data Source: STRINGDB

CTH

Tchem

Family: Enzyme

Novelty: 0.0017155

Score: 0.946

Data Source: STRINGDB

Publication Statistics

PubMed Score  111.57

PubMed score by year

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PubTator Score  34.62

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Amino-acid biosynthesis
Aminotransferase
Branched-chain amino acid biosynthesis
Complete proteome
Cytoplasm
Mitochondrion
Polymorphism

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
renal/urinary system phenotype