BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial
Protein Summary
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- ENST00000316273
- ENSP00000322991
- ENSG00000105552
- ENST00000545387
- ENSP00000440973
- BCATM
- BCT2
- ECA40
- BCAM
- BCT2
- PP18
- BCATM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.84 | ||
transcription factor | 0.77 | ||
PubMedID | 0.76 | ||
co-expressed gene | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 162.56 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 245 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 162.56 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 245 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 47
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0