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Tbio
NVL
Nuclear valosin-containing protein-like

Protein Summary
Description
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281701
  • ENSP00000281701
  • ENSG00000143748
  • ENST00000340871
  • ENSP00000341362
  • ENST00000391875
  • ENSP00000375747
  • ENST00000469075
  • ENSP00000417826
  • ENST00000469968
  • ENSP00000419420
  • ENST00000482491
  • ENSP00000417213

Symbol
  • NVL2
  • NVL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.88
molecular function
0.81
transcription factor binding site profile
0.8
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.89   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.89   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (181)
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.994453391
p_ni:  0.005546609
Score:  0.217
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.993755035
p_ni:  0.006244965
Data Source:  BioPlex
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.992279473
p_ni:  0.007720527
Data Source:  BioPlex
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.986877084
p_ni:  0.013122916
Score:  0.831
Data Source:  BioPlex,STRINGDB
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.983527347
p_ni:  0.016472653
Score:  0.19
Data Source:  BioPlex,STRINGDB
PES1
Tbio
Novelty:  0.07162845
p_int:  0.981579518
p_ni:  0.018420482
Score:  0.857
Data Source:  BioPlex,STRINGDB
MAK16
Tdark
Novelty:  0.07717917
p_int:  0.965730552
p_ni:  0.034269448
Score:  0.865
Data Source:  BioPlex,STRINGDB
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.94877586
p_ni:  0.05122414
Score:  0.229
Data Source:  BioPlex,STRINGDB
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.935852671
p_ni:  0.064147329
Data Source:  BioPlex
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.921397155
p_ni:  0.078602845
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
62.1
mean corpuscular hemoglobin concentration
1
1
1
56.4
waist circumference
1
1
1
55.2
BMI-adjusted waist circumference
1
1
1
53.7
total cholesterol measurement
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
62.1
mean corpuscular hemoglobin concentration
1
56.4
waist circumference
1
55.2
BMI-adjusted waist circumference
1
53.7
total cholesterol measurement
1
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nuclear VCP-like
702010
Mouse
MGI:1914709
67459
Rat
RGD:1311270
289323
Dog
nuclear VCP-like
VGNC:44068
480117
Horse
nuclear VCP-like
VGNC:20982
100055652
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nuclear VCP-like
Mouse
Rat
Dog
nuclear VCP-like
Horse
nuclear VCP-like
Publication Statistics
PubMed Score 8.89
PubMed score by year
PubTator Score 6.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title