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Tbio
NVL
Nuclear valosin-containing protein-like

Protein Summary
Description
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281701
  • ENSP00000281701
  • ENSG00000143748
  • ENST00000340871
  • ENSP00000341362
  • ENST00000391875
  • ENSP00000375747
  • ENST00000469075
  • ENSP00000417826
  • ENST00000469968
  • ENSP00000419420
  • ENST00000482491
  • ENSP00000417213

Symbol
  • NVL2
  • NVL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.88
molecular function
0.81
transcription factor binding site profile
0.8
drug perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.89   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.89   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
2.1
low density lipoprotein cholesterol measurement
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
2.1
low density lipoprotein cholesterol measurement
1
1.9
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (181)
1 – 10 of 181
GPATCH4
Tdark
Novelty: 1.13040547
p_int: 0.994453391
p_ni: 0.005546609
Score: 0.217
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.993755035
p_ni: 0.006244965
Data Source: BioPlex
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.992279473
p_ni: 0.007720527
Data Source: BioPlex
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.986877084
p_ni: 0.013122916
Score: 0.831
Data Source: BioPlex,STRINGDB
NPM1
Tbio
Novelty: 0.0005485
p_int: 0.983527347
p_ni: 0.016472653
Score: 0.19
Data Source: BioPlex,STRINGDB
PES1
Tbio
Novelty: 0.07162845
p_int: 0.981579518
p_ni: 0.018420482
Score: 0.857
Data Source: BioPlex,STRINGDB
MAK16
Tdark
Novelty: 0.07717917
p_int: 0.965730552
p_ni: 0.034269448
Score: 0.865
Data Source: BioPlex,STRINGDB
ZNF512
Tbio
Family: TF
Novelty: 0.08783629
p_int: 0.94877586
p_ni: 0.05122414
Score: 0.229
Data Source: BioPlex,STRINGDB
RPL11
Tbio
Novelty: 0.00448962
p_int: 0.935852671
p_ni: 0.064147329
Data Source: BioPlex
PRR11
Tbio
Novelty: 0.05077483
p_int: 0.921397155
p_ni: 0.078602845
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.89

PubMed score by year
PubTator Score  6.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer