Tclin HDAC3 Histone deacetylase 3

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15379
• D3DQE1
• O43268
• Q9UEI5
• Q9UEV0
• HD3

Gene Name

• HDAC3

Ensembl ID

• ENST00000305264
• ENSP00000302967
• ENSG00000171720

Symbol

• HD3
• RPD3
• KDAC3
• RPD3-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
molecular function	0.98
histone modification site profile	0.87
cell type or tissue	0.8

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Histone Deacetylase 3

Protein / Nucleic Acid Binding / Histone Deacetylase 3

Protein / Hydrolase / Deacetylase / Histone Deacetylase 3

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class I / Histone Deacetylase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.93   (req: < 5)

Gene RIFs: 209   (req: <= 3)

Antibodies: 845   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.93   (req: >= 5)

Gene RIFs: 209   (req: > 3)

Antibodies: 845   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1182

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5