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Tclin
HDAC3
Histone deacetylase 3

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XB ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305264
  • ENSP00000302967
  • ENSG00000171720

Symbol
  • HD3
  • RPD3
  • KDAC3
  • RPD3-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
0.98
histone modification site profile
0.87
cell type or tissue
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.84   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 845   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.84   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 845   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 805
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Active Ligands (805)
1 – 10 of 805
CHEMBL99
chemical structure image
CHEMBL27759
chemical structure image
CHEMBL408513
chemical structure image
CHEMBL356066
chemical structure image
CHEMBL2018302,CHEMBL3770936
chemical structure image
CHEMBL1213490
chemical structure image
CHEMBL272980
chemical structure image
CHEMBL598797
chemical structure image
CHEMBL1213492
chemical structure image
CHEMBL1851943,CHEMBL3215861
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (65)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Chromatin modifying enzymes
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Chromatin modifying enzymes
Gene Ontology Terms (37)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (468)
1 – 10 of 468
GPS2
Tbio
Novelty: 0.01793637
p_int: 0.999990105
p_ni: 0.000009895
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
TBL1Y
Tbio
p_int: 0.999980819
p_ni: 0.000019181
Data Source: BioPlex
ZSCAN5A
Tdark
Family: TF
Novelty: 4
p_int: 0.983696316
p_ni: 0.016303684
Score: 0.244
Data Source: BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty: 0.0389045
p_int: 0.978655801
p_ni: 0.021344089
p_wrong: 1.1e-7
Score: 0.229
Data Source: BioPlex,STRINGDB
CELA1
Tchem
Family: Enzyme
Novelty: 0.00355186
p_int: 0.944434767
p_ni: 0.055550934
p_wrong: 0.000014299
Score: 0.169
Data Source: BioPlex,STRINGDB
DGKG
Tbio
Family: Enzyme
Novelty: 0.04706767
p_int: 0.942114844
p_ni: 0.057885155
p_wrong: 1e-9
Data Source: BioPlex
CARD8
Tbio
Family: Enzyme
Novelty: 0.00962965
p_int: 0.940935638
p_ni: 0.057414604
p_wrong: 0.001649758
Data Source: BioPlex
CCT3
Tbio
Novelty: 0.00555442
p_int: 0.923828025
p_ni: 0.076170401
p_wrong: 0.000001574
Score: 0.918
Data Source: BioPlex,STRINGDB
CDK2AP1
Tbio
Family: Enzyme
Novelty: 0.00794768
p_int: 0.891059083
p_ni: 0.10893527
p_wrong: 0.000005647
Data Source: BioPlex
RFPL4B
Tdark
p_int: 0.885292341
p_ni: 0.114707659
Score: 0.16
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  165.84

PubMed score by year
PubTator Score  430.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFL
1-70
QRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFE
70-140
ASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVG
140-210
AESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECV
210-280
EYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQN
280-350
SRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
350-420
DKESDVEI
420-428
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI