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Tclin
HDAC3
Histone deacetylase 3

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XB ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305264
  • ENSP00000302967
  • ENSG00000171720

Symbol
  • HD3
  • RPD3
  • KDAC3
  • RPD3-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
0.98
histone modification site profile
0.87
cell type or tissue
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.01   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 845   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.01   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 845   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1005
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1005)
fimepinostat
Rendered image for fimepinostat
trichostatin
Rendered image for trichostatin
CUDC-101
Rendered image for CUDC-101
Belinosta
Rendered image for Belinosta
CHEMBL1830424
Rendered image for CHEMBL1830424
dacinostat
Rendered image for dacinostat
KA1010
Rendered image for KA1010
pracinostat
Rendered image for pracinostat
quisinostat
Rendered image for quisinostat
scriptaid
Rendered image for scriptaid
Protein-Protein Interactions (468)
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.999990105
p_ni:  0.000009895
Score:  0.969
Data Source:  BioPlex,Reactome,STRINGDB
TBL1Y
Tbio
p_int:  0.999980819
p_ni:  0.000019181
Data Source:  BioPlex
ZSCAN5A
Tdark
Family:  TF
Novelty:  2.15267128
p_int:  0.983696316
p_ni:  0.016303684
Score:  0.244
Data Source:  BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.978655801
p_ni:  0.021344089
p_wrong:  1.1e-7
Score:  0.229
Data Source:  BioPlex,STRINGDB
CELA1
Tchem
Family:  Enzyme
Novelty:  0.00290708
p_int:  0.944434767
p_ni:  0.055550934
p_wrong:  0.000014299
Score:  0.169
Data Source:  BioPlex,STRINGDB
DGKG
Tbio
Family:  Enzyme
Novelty:  0.03666646
p_int:  0.942114844
p_ni:  0.057885155
p_wrong:  1e-9
Data Source:  BioPlex
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.940935638
p_ni:  0.057414604
p_wrong:  0.001649758
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.923828025
p_ni:  0.076170401
p_wrong:  0.000001574
Score:  0.918
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.891059083
p_ni:  0.10893527
p_wrong:  0.000005647
Data Source:  BioPlex
RFPL4B
Tdark
Novelty:  2.42779597
p_int:  0.885292341
p_ni:  0.114707659
Score:  0.16
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
Activation of HOX genes during differentiation (R-HSA-5619507)

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Find Similar Targets
Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Chromatin modifying enzymes
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Chromatin modifying enzymes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
4
58.2
self reported educational attainment
1
2
2
53.6
mean platelet volume
2
2
2
53.1
triglyceride measurement
1
1
1
47.7
1
1
0
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
58.2
self reported educational attainment
2
53.6
mean platelet volume
2
53.1
triglyceride measurement
1
47.7
0
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 3
VGNC:4032
738624
Macaque
histone deacetylase 3
704467
Mouse
MGI:1343091
15183
Rat
RGD:619977
84578
Dog
histone deacetylase 3
VGNC:50628
478040
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 3
Macaque
histone deacetylase 3
Mouse
Rat
Dog
histone deacetylase 3
Publication Statistics
PubMed Score 194.01
PubMed score by year
PubTator Score 430.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title