Protein Classes
Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XB ...more
- ENST00000305264
- ENSP00000302967
- ENSG00000171720
- HD3
- RPD3
- KDAC3
- RPD3-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
molecular function | 0.98 | ||
histone modification site profile | 0.87 | ||
cell type or tissue | 0.8 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 194.01 (req: < 5)
Gene RIFs: 161 (req: <= 3)
Antibodies: 845 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 194.01 (req: >= 5)
Gene RIFs: 161 (req: > 3)
Antibodies: 845 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1005
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Approved Drugs (5)
1 – 5 of 5
Active Ligands (1005)
1 – 10 of 1005
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 2 | 4 | 58.2 | |||||
self reported educational attainment | 1 | 2 | 2 | 53.6 | |||||
mean platelet volume | 2 | 2 | 2 | 53.1 | |||||
triglyceride measurement | 1 | 1 | 1 | 47.7 | |||||
1 | 1 | 0 | 1 | 46.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 58.2 | |||||
self reported educational attainment | 2 | 53.6 | |||||
mean platelet volume | 2 | 53.1 | |||||
triglyceride measurement | 1 | 47.7 | |||||
0 | 1 | 46.5 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histone deacetylase 3 | VGNC:4032 | 738624 | |||||
Macaque | histone deacetylase 3 | 704467 | ||||||
Mouse | MGI:1343091 | 15183 | ||||||
Rat | RGD:619977 | 84578 | ||||||
Dog | histone deacetylase 3 | VGNC:50628 | 478040 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histone deacetylase 3 | |||||
Macaque | histone deacetylase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone deacetylase 3 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (65)
Reactome (50)
KEGG (3)
PathwayCommons (7)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 50
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Association of TriC/CCT with target proteins during biosynthesis | ||||
Reactome | Chaperonin-mediated protein folding | ||||
Reactome | Chromatin modifying enzymes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Association of TriC/CCT with target proteins during biosynthesis | ||||
Chaperonin-mediated protein folding | ||||
Chromatin modifying enzymes | ||||
Gene Ontology Terms (37)
Functions (10)
Components (9)
Processes (18)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (468)
1 – 10 of 468
GPS2
Novelty: 0.00986158
p_int: 0.999990105
p_ni: 0.000009895
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
TBL1Y
p_int: 0.999980819
p_ni: 0.000019181
Data Source: BioPlex
ZSCAN5A
Family: TF
Novelty: 2.15267128
p_int: 0.983696316
p_ni: 0.016303684
Score: 0.244
Data Source: BioPlex,STRINGDB
HNRNPLL
Novelty: 0.0498467
p_int: 0.978655801
p_ni: 0.021344089
p_wrong: 1.1e-7
Score: 0.229
Data Source: BioPlex,STRINGDB
CELA1
Family: Enzyme
Novelty: 0.00290708
p_int: 0.944434767
p_ni: 0.055550934
p_wrong: 0.000014299
Score: 0.169
Data Source: BioPlex,STRINGDB
DGKG
Family: Enzyme
Novelty: 0.03666646
p_int: 0.942114844
p_ni: 0.057885155
p_wrong: 1e-9
Data Source: BioPlex
CARD8
Family: Enzyme
Novelty: 0.0146799
p_int: 0.940935638
p_ni: 0.057414604
p_wrong: 0.001649758
Data Source: BioPlex
CCT3
Novelty: 0.01642521
p_int: 0.923828025
p_ni: 0.076170401
p_wrong: 0.000001574
Score: 0.918
Data Source: BioPlex,STRINGDB
CDK2AP1
Family: Enzyme
Novelty: 0.01584718
p_int: 0.891059083
p_ni: 0.10893527
p_wrong: 0.000005647
Data Source: BioPlex
RFPL4B
Novelty: 2.42779597
p_int: 0.885292341
p_ni: 0.114707659
Score: 0.16
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 194.01
PubMed score by year
PubTator Score 430.68
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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GWAS Trait
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