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Tclin
HDAC3
Histone deacetylase 3

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XB ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305264
  • ENSP00000302967
  • ENSG00000171720

Symbol
  • HD3
  • RPD3
  • KDAC3
  • RPD3-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
0.98
histone modification site profile
0.87
cell type or tissue
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.93   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 845   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.93   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 845   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1182
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5