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Tdark
SLC16A5
Monocarboxylate transporter 6

Protein Summary
Description
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329783
  • ENSP00000330141
  • ENSG00000170190
  • ENST00000450736
  • ENSP00000390564
  • ENST00000538213
  • ENSP00000440212
  • ENST00000580123
  • ENSP00000463434

Symbol
  • MCT5
  • MCT6
  • MCT5
  • MCT6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
0.92
transcription factor
0.73
PubMedID
0.68
kinase perturbation
0.66


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 16 member 5
VGNC:9617
454874
Mouse
MGI:2443515
217316
Rat
RGD:1582896
690212
Horse
solute carrier family 16 member 5 [Source:HGNC Symbol;Acc:HGNC:10926]
Cow
solute carrier family 16 member 5
VGNC:34691
531531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 16 member 5
Mouse
Rat
Horse
solute carrier family 16 member 5 [Source:HGNC Symbol;Acc:HGNC:10926]
Cow
solute carrier family 16 member 5
Protein-Protein Interactions (34)
1 – 10 of 34
SLC5A6
Tbio
Family: Transporter
Novelty: 0.0126926
Score: 0.652
Data Source: STRINGDB
HSD17B12
Tbio
Family: Enzyme
Novelty: 0.02200219
Score: 0.628
Data Source: STRINGDB
SLC30A10
Tbio
Family: Transporter
Novelty: 0.00448153
Score: 0.576
Data Source: STRINGDB
ABCA2
Tbio
Family: Transporter
Novelty: 0.02208136
Score: 0.561
Data Source: STRINGDB
FAM208A
Tbio
Novelty: 0.17789689
Score: 0.553
Data Source: STRINGDB
SLC37A1
Tbio
Family: Transporter
Novelty: 0.11329328
Score: 0.55
Data Source: STRINGDB
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
Score: 0.549
Data Source: STRINGDB
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
Score: 0.524
Data Source: STRINGDB
SLC39A8
Tbio
Family: Transporter
Novelty: 0.00923197
Score: 0.523
Data Source: STRINGDB
SLC26A2
Tbio
Family: Transporter
Novelty: 0.00325201
Score: 0.52
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.54

PubMed score by year
PubTator Score  3.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer