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Tbio
EIF3H
Eukaryotic translation initiation factor 3 subunit H

Protein Classes
Protein Summary
Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repressi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000521861
  • ENSP00000429931
  • ENSG00000147677

Symbol
  • EIF3S3
  • EIF3S3
  • eIF3-p40
  • eIF3-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
co-expressed gene
0.85
virus perturbation
0.85
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.87   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.87   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (230)
1 – 10 of 230
EIF3E
Tbio
Novelty: 0.02690754
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3F
Tbio
Novelty: 0.03659119
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3I
Tbio
Novelty: 0.07521172
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3L
Tbio
Novelty: 0.1477297
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3M
Tbio
Novelty: 0.02340046
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3CL
Tdark
Novelty: 0.96335941
p_int: 0.999999993
p_ni: 7e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3G
Tbio
Novelty: 0.06880717
p_int: 0.999999899
p_ni: 1.01e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PRRC2B
Tdark
Novelty: 0.51051051
p_int: 0.999996705
p_ni: 0.000003294
p_wrong: 1e-9
Score: 0.817
Data Source: BioPlex,STRINGDB
EIF3A
Tbio
Novelty: 0.00483199
p_int: 0.999990805
p_ni: 0.000009195
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF3C
Tbio
Novelty: 0.05352423
p_int: 0.999971676
p_ni: 0.000028324
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  30.87

PubMed score by year
PubTator Score  20.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGL
1-70
VVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSY
70-140
QHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHL
140-210
INVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQR
210-280
RQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEY
280-350
NN
350-352
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN