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Tchem
INPPL1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

Protein Summary
Description
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298229
  • ENSP00000298229
  • ENSG00000165458
  • ENST00000538751
  • ENSP00000444619

Symbol
  • SHIP2
  • OPSMD
  • SHIP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
disease perturbation
0.93
protein domain
0.85
cell line
0.83
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.27   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.27   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (209)
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.999998991
p_ni:  0.000001009
Score:  0.298
Data Source:  BioPlex,STRINGDB
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.999994066
p_ni:  0.000005934
Score:  0.176
Data Source:  BioPlex,STRINGDB
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.999989829
p_ni:  0.000010171
Data Source:  BioPlex
THRSP
Tbio
Novelty:  0.00938864
p_int:  0.999985436
p_ni:  0.000014564
Data Source:  BioPlex
SAMD4A
Tbio
Novelty:  0.04440962
p_int:  0.9999457
p_ni:  0.0000543
Score:  0.15
Data Source:  BioPlex,STRINGDB
DYDC2
Tdark
Novelty:  1.40061645
p_int:  0.999938202
p_ni:  0.000061798
Data Source:  BioPlex
RRM2
Tclin
Family:  Enzyme
Novelty:  0.00112948
p_int:  0.999919592
p_ni:  0.000080408
Score:  0.702
Data Source:  BioPlex,STRINGDB
TPD52L2
Tbio
Novelty:  0.03500169
p_int:  0.999879466
p_ni:  0.000120534
Score:  0.207
Data Source:  BioPlex,STRINGDB
MAPK4
Tbio
Family:  Kinase
Novelty:  0.0223868
p_int:  0.999625876
p_ni:  0.000374124
Data Source:  BioPlex
BHMT2
Tchem
Family:  Enzyme
Novelty:  0.07713739
p_int:  0.999263155
p_ni:  0.000736845
Score:  0.253
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (65)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Inositol phosphate metabolism
Reactome
Interleukin receptor SHC signaling
Reactome
Interleukin-2 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Inositol phosphate metabolism
Interleukin receptor SHC signaling
Interleukin-2 family signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
66.3
electrocardiography
1
1
1
15.8
heart rate response to recovery post exercise
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
66.3
electrocardiography
1
15.8
heart rate response to recovery post exercise
1
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate phosphatase like 1
VGNC:3251
451403
Macaque
inositol polyphosphate phosphatase like 1
718421
Mouse
MGI:1333787
16332
Rat
RGD:68396
65038
Dog
inositol polyphosphate phosphatase like 1
VGNC:42037
485209
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate phosphatase like 1
Macaque
inositol polyphosphate phosphatase like 1
Mouse
Rat
Dog
inositol polyphosphate phosphatase like 1
Publication Statistics
PubMed Score 212.27
PubMed score by year
PubTator Score 133.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title