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Tbio
PPM1G
Protein phosphatase 1G

Protein Summary
Description
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344034
  • ENSP00000342778
  • ENSG00000115241

Symbol
  • PPM1C
  • PP2CG
  • PPP2CG
  • PP2CGAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
kinase perturbation
0.99
transcription factor binding site profile
0.91
transcription factor
0.85
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.48   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.48   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (116)
1 – 10 of 116
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999359457
p_ni:  0.000640543
Score:  0.459
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999292722
p_ni:  0.000707278
Score:  0.191
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.98802782
p_ni:  0.01197218
Score:  0.155
Data Source:  BioPlex,STRINGDB
CPA6
Tbio
Family:  Enzyme
Novelty:  0.05034597
p_int:  0.9546897
p_ni:  0.0453103
Score:  0.19
Data Source:  BioPlex,STRINGDB
CERKL
Tbio
Family:  Enzyme
Novelty:  0.04190552
p_int:  0.928826109
p_ni:  0.071173891
Score:  0.21
Data Source:  BioPlex,STRINGDB
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.919952363
p_ni:  0.080047637
Score:  0.18
Data Source:  BioPlex,STRINGDB
ZNF223
Tdark
Family:  TF
Novelty:  0.78390275
p_int:  0.811587145
p_ni:  0.188412855
Score:  0.216
Data Source:  BioPlex,STRINGDB
TCEANC2
Tdark
Novelty:  0.40325323
p_int:  0.796690537
p_ni:  0.203309462
p_wrong:  1e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
PSD2
Tdark
Novelty:  0.03272803
p_int:  0.796547016
p_ni:  0.203452984
Data Source:  BioPlex
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.75558642
p_ni:  0.24441358
Score:  0.204
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (104)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
25
20
49
5.1
99.9
C-reactive protein measurement
7
6
13
99.4
total cholesterol measurement
8
7
11
3.9
99.3
apolipoprotein B measurement
2
6
6
99.1
serum gamma-glutamyl transferase measurement
6
5
8
3.2
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
49
5.1
99.9
C-reactive protein measurement
13
99.4
total cholesterol measurement
11
3.9
99.3
apolipoprotein B measurement
6
99.1
serum gamma-glutamyl transferase measurement
8
3.2
99
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1G
VGNC:8256
470340
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1G
700695
Mouse
MGI:106065
14208
Rat
RGD:628676
259229
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1G
VGNC:44867
475703
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1G
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1G
Mouse
Rat
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1G
Publication Statistics
PubMed Score 38.48
PubMed score by year
PubTator Score 15.38
PubTator score by year