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Tbio
GPR37
Prosaposin receptor GPR37

Protein Summary
Description
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303921
  • ENSP00000306449
  • ENSG00000170775

Symbol
  • PAELR
  • EDNRBL
  • hET(B)R-LP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
disease perturbation
0.74
biological process
0.65
molecular function
0.63
tissue sample
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.74   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.74   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Genetic Construct
GPR37-Tango
image for GPR37-Tango
Details:
  • Vector:  addgene66355
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR37-Tango
Order Genetic Construct from:
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
64.4
mean corpuscular volume
1
1
1
56.8
2
1
0
2.4
49.5
2
2
0
1.2
39.5
telomere length
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
64.4
mean corpuscular volume
1
56.8
0
2.4
49.5
0
1.2
39.5
telomere length
1
35
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 37
VGNC:8685
738926
Macaque
G protein-coupled receptor 37
696628
Mouse
MGI:1313297
14763
Rat
RGD:619848
117549
Dog
G protein-coupled receptor 37
VGNC:41432
482275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 37
Macaque
G protein-coupled receptor 37
Mouse
Rat
Dog
G protein-coupled receptor 37
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15354-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (20)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (306)
1 – 10 of 306
NXF1
Tbio
Novelty:  0.00642439
p_int:  0.999920407
p_ni:  0.000079593
Score:  0.189
Data Source:  BioPlex,STRINGDB
FAM219A
Tdark
Novelty:  12.35294118
p_int:  0.999247717
p_ni:  0.000750236
p_wrong:  0.000002048
Score:  0.802
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.964407537
p_ni:  0.029418937
p_wrong:  0.006173525
Score:  0.228
Data Source:  BioPlex,STRINGDB
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.849821646
p_ni:  0.149315713
p_wrong:  0.000862641
Score:  0.534
Data Source:  BioPlex,STRINGDB
ABCB8
Tbio
Family:  Transporter
Novelty:  0.08074055
p_int:  0.849141441
p_ni:  0.150858559
Score:  0.173
Data Source:  BioPlex,STRINGDB
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.848525226
p_ni:  0.151474774
Score:  0.514
Data Source:  BioPlex,STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.84183063
p_ni:  0.051316101
p_wrong:  0.106853269
Score:  0.183
Data Source:  BioPlex,STRINGDB
POLD2
Tbio
Family:  Enzyme
Novelty:  0.05932998
p_int:  0.832827945
p_ni:  0.156145477
p_wrong:  0.011026578
Score:  0.19
Data Source:  BioPlex,STRINGDB
MBOAT7
Tbio
Family:  Enzyme
Novelty:  0.01861411
p_int:  0.754130755
p_ni:  0.245582749
p_wrong:  0.000286496
Data Source:  BioPlex
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.98
Data Source:  STRINGDB
Publication Statistics
PubMed Score  61.74

PubMed score by year
PubTator Score  37.31

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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