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Tbio
TP73
Tumor protein p73

Protein Summary
Description
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346387
  • ENSP00000340740
  • ENSG00000078900
  • ENST00000354437
  • ENSP00000346423
  • ENST00000357733
  • ENSP00000350366
  • ENST00000378285
  • ENSP00000367534
  • ENST00000378288
  • ENSP00000367537
  • ENST00000378290
  • ENSP00000367539
  • ENST00000378295
  • ENSP00000367545
  • ENST00000603362
  • ENSP00000474626
  • ENST00000604074
  • ENSP00000475143
  • ENST00000604479
  • ENSP00000474322

Symbol
  • P73
  • P73
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.99
molecular function
0.98
kinase
0.97
protein domain
0.97


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.28   (req: < 5)
Gene RIFs: 478   (req: <= 3)
Antibodies: 1008   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.28   (req: >= 5)
Gene RIFs: 478   (req: > 3)
Antibodies: 1008   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor protein p73
100611345
Macaque
tumor protein p73
695164
Mouse
MGI:1336991
22062
Rat
RGD:1307083
362675
Dog
tumor protein p73
VGNC:47730
489620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor protein p73
Macaque
tumor protein p73
Mouse
Rat
Dog
tumor protein p73
Protein Data Bank (21)
1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (109)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of PUMA and translocation to mitochondria
Apoptosis
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (43)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (208)
1 – 10 of 208
TP63
Tbio
Family: TF
Novelty: 0.00336108
p_int: 0.999996122
p_ni: 0.000003878
Score: 0.982
Data Source: BioPlex,STRINGDB
MDM4
Tchem
Novelty: 0.00321558
p_int: 0.999136292
p_ni: 0.000863708
Score: 0.809
Data Source: BioPlex,STRINGDB
IER2
Tbio
Novelty: 0.03864806
p_int: 0.967098979
p_ni: 0.032901021
Data Source: BioPlex
HASPIN
Tchem
Family: Kinase
Novelty: 0.01574198
p_int: 0.950747756
p_ni: 0.049252244
p_wrong: 1e-9
Data Source: BioPlex
L3MBTL1
Tchem
Family: TF; Epigenetic
Novelty: 0.02321712
p_int: 0.950379344
p_ni: 0.049620656
Score: 0.263
Data Source: BioPlex,STRINGDB
PRELID2
Tdark
Novelty: 0.38276284
p_int: 0.930118207
p_ni: 0.069881793
Data Source: BioPlex
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.870840385
p_ni: 0.129159615
Data Source: BioPlex
SKP2
Tbio
Family: Enzyme
Novelty: 0.00182658
p_int: 0.754209772
p_ni: 0.245790228
Score: 0.216
Data Source: BioPlex,STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
Score: 0.998
Data Source: STRINGDB
TP53BP2
Tbio
Novelty: 0.01058379
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  144.28

PubMed score by year
PubTator Score  947.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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