Protein Summary
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
- ENST00000346387
- ENSP00000340740
- ENSG00000078900
- ENST00000354437
- ENSP00000346423
- ENST00000357733
- ENSP00000350366
- ENST00000378285
- ENSP00000367534
- ENST00000378288
- ENSP00000367537
- ENST00000378290
- ENSP00000367539
- ENST00000378295
- ENSP00000367545
- ENST00000603362
- ENSP00000474626
- ENST00000604074
- ENSP00000475143
- ENST00000604479
- ENSP00000474322
- P73
- P73
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
hub protein | 0.99 | ||
molecular function | 0.98 | ||
kinase | 0.97 | ||
protein domain | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.56 (req: < 5)
Gene RIFs: 478 (req: <= 3)
Antibodies: 1008 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.56 (req: >= 5)
Gene RIFs: 478 (req: > 3)
Antibodies: 1008 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (208)
TP63
Family: TF
Novelty: 0.00336108
p_int: 0.999996122
p_ni: 0.000003878
Score: 0.982
Data Source: BioPlex,STRINGDB
MDM4
Novelty: 0.00321558
p_int: 0.999136292
p_ni: 0.000863708
Score: 0.809
Data Source: BioPlex,STRINGDB
HASPIN
Family: Kinase
Novelty: 0.01574198
p_int: 0.950747756
p_ni: 0.049252244
p_wrong: 1e-9
Data Source: BioPlex
L3MBTL1
Family: TF; Epigenetic
Novelty: 0.02321712
p_int: 0.950379344
p_ni: 0.049620656
Score: 0.263
Data Source: BioPlex,STRINGDB
SKP2
Family: Enzyme
Novelty: 0.00182658
p_int: 0.754209772
p_ni: 0.245790228
Score: 0.216
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (109)
Reactome (18)
KEGG (4)
PathwayCommons (10)
WikiPathways (77)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of BH3-only proteins | ||||
Reactome | Activation of PUMA and translocation to mitochondria | ||||
Reactome | Apoptosis | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of BH3-only proteins | ||||
Activation of PUMA and translocation to mitochondria | ||||
Apoptosis | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (43)
Functions (11)
Components (8)
Processes (24)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 3 | 7 | 96.6 | |||||
reticulocyte count | 7 | 2 | 9 | 94.7 | |||||
reticulocyte measurement | 3 | 2 | 5 | 94.3 | |||||
hemoglobin measurement | 3 | 2 | 3 | 91.9 | |||||
mean corpuscular volume | 1 | 1 | 1 | 86.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 7 | 96.6 | |||||
reticulocyte count | 9 | 94.7 | |||||
reticulocyte measurement | 5 | 94.3 | |||||
hemoglobin measurement | 3 | 91.9 | |||||
mean corpuscular volume | 1 | 86.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tumor protein p73 | 100611345 | ||||||
Macaque | tumor protein p73 | 695164 | ||||||
Mouse | MGI:1336991 | 22062 | ||||||
Rat | RGD:1307083 | 362675 | ||||||
Dog | tumor protein p73 | VGNC:47730 | 489620 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tumor protein p73 | |||||
Macaque | tumor protein p73 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tumor protein p73 | |||||
Publication Statistics
PubMed Score 153.56
PubMed score by year
PubTator Score 947.30
PubTator score by year
Related Publications
Text Mined References (558)
GeneRif Annotations (478)
Items per page:
0 of 0
PMID | Year | Title |
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