Tbio TP73 Tumor protein p73

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Tumor Protein P73

Protein / ... / P53-like Transcription Factor / Tumor Protein P73

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / P53-like Transcription Factor / Tumor Protein P73

Protein Summary

Description

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• O15350
• B7Z7J4
• B7Z8Z1
• B7Z9C1
• C9J521
• O15351
• Q17RN8
• Q5TBV5
• Q5TBV6
• Q8NHW9
• Q8TDY5
• Q8TDY6
• Q9NTK8

Gene Name

• TP73

Ensembl ID

• ENST00000346387
• ENSP00000340740
• ENSG00000078900
• ENST00000354437
• ENSP00000346423
• ENST00000357733
• ENSP00000350366
• ENST00000378285
• ENSP00000367534
• ENST00000378288
• ENSP00000367537
• ENST00000378290
• ENSP00000367539
• ENST00000378295
• ENSP00000367545
• ENST00000603362
• ENSP00000474626
• ENST00000604074
• ENSP00000475143
• ENST00000604479
• ENSP00000474322

Symbol

• P73
• P73

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	0.99
molecular function	0.98
kinase	0.97
protein domain	0.97

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.28   (req: < 5)

Gene RIFs: 478   (req: <= 3)

Antibodies: 1008   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.28   (req: >= 5)

Gene RIFs: 478   (req: > 3)

Antibodies: 1008   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tumor protein p73		100611345
Macaque	tumor protein p73		695164
Mouse	transformation related protein 73	MGI:1336991	22062
Rat	tumor protein p73	RGD:1307083	362675
Dog	tumor protein p73	VGNC:47730	489620

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tumor protein p73
Macaque	tumor protein p73
Mouse	transformation related protein 73
Rat	tumor protein p73
Dog	tumor protein p73

Protein Data Bank (21)

1 – 5 of 21

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (109)

Reactome (18)

KEGG (4)

PathwayCommons (10)

WikiPathways (77)

Activation of BH3-only proteins (R-HSA-114452)

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Items per page:

5

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of BH3-only proteins	31 targets	R-HSA-114452
Reactome	Activation of PUMA and translocation to mitochondria	10 targets	R-HSA-139915
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Activation of BH3-only proteins	31 targets	R-HSA-114452
Activation of PUMA and translocation to mitochondria	10 targets	R-HSA-139915
Apoptosis	177 targets	R-HSA-109581
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (43)

Functions (11)

Components (8)

Processes (24)

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Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	MGI
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
MDM2/MDM4 family protein binding	Inferred from Physical Interaction (IPI)	CAFA
p53 binding	Inferred from Physical Interaction (IPI)	CAFA
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
transcription factor binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL

Protein-Protein Interactions (208)

Explore Interacting Targets

1 – 10 of 208

• See Interactions on String-DB

TP63

Tbio

Family: TF

Novelty: 0.00336108

p_int: 0.999996122

p_ni: 0.000003878

Score: 0.982

Data Source: BioPlex,STRINGDB

MDM4

Tchem

Novelty: 0.00321558

p_int: 0.999136292

p_ni: 0.000863708

Score: 0.809

Data Source: BioPlex,STRINGDB

IER2

Tbio

Novelty: 0.03864806

p_int: 0.967098979

p_ni: 0.032901021

Data Source: BioPlex

HASPIN

Tchem

Family: Kinase

Novelty: 0.01574198

p_int: 0.950747756

p_ni: 0.049252244

p_wrong: 1e-9

Data Source: BioPlex

L3MBTL1

Tchem

Family: TF; Epigenetic

Novelty: 0.02321712

p_int: 0.950379344

p_ni: 0.049620656

Score: 0.263

Data Source: BioPlex,STRINGDB

PRELID2

Tdark

Novelty: 0.38276284

p_int: 0.930118207

p_ni: 0.069881793

Data Source: BioPlex

C6orf141

Tdark

Novelty: 1.46022784

p_int: 0.870840385

p_ni: 0.129159615

Data Source: BioPlex

SKP2

Tbio

Family: Enzyme

Novelty: 0.00182658

p_int: 0.754209772

p_ni: 0.245790228

Score: 0.216

Data Source: BioPlex,STRINGDB

MDM2

Tchem

Family: Enzyme

Novelty: 0.00028385

Score: 0.998

Data Source: STRINGDB

TP53BP2

Tbio

Novelty: 0.01058379

Score: 0.992

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  144.28

PubMed score by year

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PubTator Score  947.3

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Activator
Alternative promoter usage
Alternative splicing
Apoptosis
Cell cycle
Complete proteome
Cytoplasm
DNA-binding
Host-virus interaction

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype