Protein Summary
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
- ENST00000346387
- ENSP00000340740
- ENSG00000078900
- ENST00000354437
- ENSP00000346423
- ENST00000357733
- ENSP00000350366
- ENST00000378285
- ENSP00000367534
- ENST00000378288
- ENSP00000367537
- ENST00000378290
- ENSP00000367539
- ENST00000378295
- ENSP00000367545
- ENST00000603362
- ENSP00000474626
- ENST00000604074
- ENSP00000475143
- ENST00000604479
- ENSP00000474322
- P73
- P73
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
hub protein | 0.99 | ||
molecular function | 0.98 | ||
kinase | 0.97 | ||
protein domain | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 179.12 (req: < 5)
Gene RIFs: 539 (req: <= 3)
Antibodies: 1008 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 179.12 (req: >= 5)
Gene RIFs: 539 (req: > 3)
Antibodies: 1008 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0