You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MID1
E3 ubiquitin-protein ligase Midline-1

Protein Summary
Description
Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317552
  • ENSP00000312678
  • ENSG00000101871
  • ENST00000380779
  • ENSP00000370156
  • ENST00000380780
  • ENSP00000370157
  • ENST00000380782
  • ENSP00000370159
  • ENST00000380785
  • ENSP00000370162
  • ENST00000380787
  • ENSP00000370164
  • ENST00000453318
  • ENSP00000414521

Symbol
  • FXY
  • RNF59
  • TRIM18
  • XPRF
  • OS
  • FXY
  • OSX
  • OGS1
  • XPRF
  • BBBG1
  • GBBB1
  • MIDIN
  • RNF59
  • ZNFXY
  • TRIM18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
ligand (protein) perturbation
0.96
transcription factor perturbation
0.96
microRNA
0.81
transcription factor
0.81


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.14   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.14   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
midline 1
VGNC:2700
741750
Macaque
midline 1
709683
Mouse
MGI:1100537
17318
Rat
RGD:2640
54252
Dog
midline 1
VGNC:43222
491737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
midline 1
Macaque
midline 1
Mouse
Rat
Dog
midline 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15344-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (18)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (190)
1 – 10 of 190
IL6R
Tclin
Novelty:  0.00185005
p_int:  0.999999686
p_ni:  3.05e-7
p_wrong:  9e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.999999219
p_ni:  7.81e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
GSTT1
Tbio
Family:  Enzyme
p_int:  0.999978266
p_ni:  0.000021727
p_wrong:  8e-9
Data Source:  BioPlex
EPN3
Tbio
Novelty:  0.12685855
p_int:  0.999978136
p_ni:  0.000021864
Score:  0.219
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.999947717
p_ni:  0.000052232
p_wrong:  5.1e-8
Data Source:  BioPlex
MLLT6
Tdark
Family:  Epigenetic
Novelty:  0.03728427
p_int:  0.999918549
p_ni:  0.000081444
p_wrong:  7e-9
Score:  0.164
Data Source:  BioPlex,STRINGDB
CDKN2AIP
Tbio
Novelty:  0.15331029
p_int:  0.999893085
p_ni:  0.00010664
p_wrong:  2.75e-7
Data Source:  BioPlex
ZFYVE1
Tbio
Novelty:  0.00372406
p_int:  0.999854238
p_ni:  0.000145629
p_wrong:  1.33e-7
Score:  0.215
Data Source:  BioPlex,STRINGDB
ZBTB42
Tbio
Family:  TF
Novelty:  0.54038505
p_int:  0.999851663
p_ni:  0.000148337
Score:  0.22
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.99982716
p_ni:  0.000170756
p_wrong:  0.000002084
Data Source:  BioPlex
Publication Statistics
PubMed Score  46.14

PubMed score by year
PubTator Score  89.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: