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Tbio
ATP6V0E1
V-type proton ATPase subunit e 1

Protein Summary
Description
Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000517669
  • ENSP00000427941
  • ENSG00000113732
  • ENST00000519374
  • ENSP00000429690

Symbol
  • ATP6H
  • ATP6V0E
  • M9.2
  • ATP6H
  • Vma21
  • Vma21p
  • ATP6V0E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.98
molecular function
0.91
transcription factor binding site profile
0.84
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.32   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.32   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
1
1
0
1.5
14.1
body mass index
1
1
1
13.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
0
1.5
14.1
body mass index
1
13.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit e1
VGNC:8616
740323
Macaque
ATPase H+ transporting V0 subunit e1
703342
Mouse
MGI:1328318
11974
Rat
RGD:621393
94170
Dog
ATPase H+ transporting V0 subunit e1
VGNC:38275
403729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit e1
Macaque
ATPase H+ transporting V0 subunit e1
Mouse
Rat
Dog
ATPase H+ transporting V0 subunit e1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15342-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (71)
1 – 10 of 71
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.998769399
p_ni:  0.001230601
Score:  0.989
Data Source:  BioPlex,STRINGDB
CCDC115
Tbio
Novelty:  0.23966137
p_int:  0.998673354
p_ni:  0.001180554
p_wrong:  0.000146092
Score:  0.783
Data Source:  BioPlex,STRINGDB
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.998352683
p_ni:  0.001545249
p_wrong:  0.000102068
Score:  0.872
Data Source:  BioPlex,STRINGDB
VMA21
Tdark
Family:  Enzyme
Novelty:  0.46129032
p_int:  0.997681661
p_ni:  0.001847808
p_wrong:  0.000470531
Score:  0.676
Data Source:  BioPlex,STRINGDB
SLC7A2
Tbio
Family:  Transporter
Novelty:  0.02262224
p_int:  0.997464508
p_ni:  0.002535492
Data Source:  BioPlex
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.984910771
p_ni:  0.015089229
Score:  0.987
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.879649555
p_ni:  0.120350183
p_wrong:  2.62e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
PTPRF
Tchem
Family:  Enzyme
Novelty:  0.01017327
p_int:  0.869414458
p_ni:  0.130585542
Score:  0.173
Data Source:  BioPlex,STRINGDB
PIGG
Tbio
Family:  Enzyme
Novelty:  0.01573185
p_int:  0.817756062
p_ni:  0.182243938
Score:  0.209
Data Source:  BioPlex,STRINGDB
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
p_int:  0.788514785
p_ni:  0.211335843
p_wrong:  0.000149371
Score:  0.159
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.32

PubMed score by year
PubTator Score  5.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer