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Tbio
POLR3G
DNA-directed RNA polymerase III subunit RPC7

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399107
  • ENSP00000382058
  • ENSG00000113356
  • ENST00000504930
  • ENSP00000421637

Symbol
  • RPC7
  • RPC32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
gene perturbation
0.76
histone modification site profile
0.76
disease perturbation
0.74
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.41   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.41   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.927
Data Source:  BioPlex,STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.999999938
p_ni:  1.9e-8
p_wrong:  4.3e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
POLR3E
Tbio
Family:  Enzyme
Novelty:  0.06500715
p_int:  0.99999489
p_ni:  0.000004084
p_wrong:  0.000001026
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  0.99999467
p_ni:  6e-9
p_wrong:  0.000005324
Score:  0.994
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.999977607
p_ni:  0.000022384
p_wrong:  9e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.996327916
p_ni:  0.000555764
p_wrong:  0.00311632
Score:  0.175
Data Source:  BioPlex,STRINGDB
POLR3F
Tbio
Family:  Enzyme
Novelty:  0.0805125
Score:  0.999
Data Source:  Reactome,STRINGDB
POLR3H
Tbio
Family:  Enzyme
Novelty:  0.16483597
Score:  0.999
Data Source:  STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
Score:  0.996
Data Source:  Reactome,STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit G
VGNC:8632
461759
Macaque
RNA polymerase III subunit G
695330
Mouse
MGI:1914736
67486
Rat
RGD:1593792
685465
Dog
RNA polymerase III subunit G
VGNC:44805
609731
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit G
Macaque
RNA polymerase III subunit G
Mouse
Rat
Dog
RNA polymerase III subunit G
Publication Statistics
PubMed Score 22.41
PubMed score by year
PubTator Score 6.65
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title