You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RAD51B
DNA repair protein RAD51 homolog 2

Protein Summary
Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. The protein encoded by this gene is a member of the RAD5 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000471583
  • ENSP00000418859
  • ENSG00000182185
  • ENST00000487270
  • ENSP00000419471
  • ENST00000488612
  • ENSP00000420061

Symbol
  • RAD51L1
  • REC2
  • REC2
  • R51H2
  • RAD51L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
trait
0.86
disease
0.73
protein domain
0.73
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.75   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.75   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (13)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Factors involved in megakaryocyte development and platelet production
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Protein-Protein Interactions (215)
1 – 10 of 215
XRCC2
Tbio
Novelty: 0.00954601
p_int: 0.999935327
p_ni: 0.000064673
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
DKKL1
Tbio
Novelty: 0.00579782
p_int: 0.999410786
p_ni: 0.000589213
p_wrong: 1e-9
Data Source: BioPlex
ARL4C
Tbio
Family: Enzyme
Novelty: 0.0705892
p_int: 0.994077031
p_ni: 0.005909009
p_wrong: 0.000013961
Score: 0.554
Data Source: BioPlex,STRINGDB
MUC20
Tbio
Novelty: 0.07155729
p_int: 0.95164372
p_ni: 0.048332776
p_wrong: 0.000023504
Data Source: BioPlex
ADAMTS4
Tchem
Family: Enzyme
Novelty: 0.00578587
p_int: 0.946915717
p_ni: 0.00386059
p_wrong: 0.049223693
Score: 0.161
Data Source: BioPlex,STRINGDB
BRCA1
Tchem
Novelty: 0.00014684
Score: 0.992
Data Source: STRINGDB
BRCA2
Tbio
Novelty: 0.00031192
Score: 0.992
Data Source: STRINGDB
RAD51D
Tbio
Novelty: 0.02711092
Score: 0.991
Data Source: Reactome,STRINGDB
RAD1
Tchem
Novelty: 0.01108306
Score: 0.99
Data Source: STRINGDB
MRE11
Tbio
Novelty: 0.00847079
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.75

PubMed score by year
PubTator Score  72.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: