Tbio RAD51B DNA repair protein RAD51 homolog 2

Protein Summary

Description

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• O15315
• O60914
• O75210
• Q3Y4F8
• Q6FHX8
• Q86SY3
• Q86SY4
• Q86TR0
• Q86U92
• Q86U93
• Q86U94
• Q8N6H4
• Q9UPL5
• R51H2

Gene Name

• RAD51B

Ensembl ID

• ENST00000471583
• ENSP00000418859
• ENSG00000182185
• ENST00000487270
• ENSP00000419471
• ENST00000488612
• ENSP00000420061

Symbol

• RAD51L1
• REC2
• REC2
• R51H2
• RAD51L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
trait	0.86
disease	0.73
protein domain	0.73
transcription factor binding site profile	0.73

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.75   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.75   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (13)

Reactome (12)

KEGG (1)

DNA Double-Strand Break Repair (R-HSA-5693532)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DNA Double-Strand Break Repair	146 targets	R-HSA-5693532
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	HDR through Homologous Recombination (HRR)	66 targets	R-HSA-5685942
Reactome	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	112 targets	R-HSA-5693567

Name	Explore in Pharos	Explore in Source
DNA Double-Strand Break Repair	146 targets	R-HSA-5693532
DNA Repair	306 targets	R-HSA-73894
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
HDR through Homologous Recombination (HRR)	66 targets	R-HSA-5685942
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	112 targets	R-HSA-5693567

Gene Ontology Terms (15)

Functions (5)

Components (4)

Processes (6)

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1 – 5 of 5

GO Term	Evidence	Assigned by
DNA-dependent ATPase activity	Inferred from Direct Assay (IDA)	UniProtKB
double-stranded DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
single-stranded DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (215)

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1 – 10 of 215

• See Interactions on String-DB

XRCC2

Tbio

Novelty: 0.00954601

p_int: 0.999935327

p_ni: 0.000064673

Score: 0.989

Data Source: BioPlex,Reactome,STRINGDB

DKKL1

Tbio

Novelty: 0.00579782

p_int: 0.999410786

p_ni: 0.000589213

p_wrong: 1e-9

Data Source: BioPlex

ARL4C

Tbio

Family: Enzyme

Novelty: 0.0705892

p_int: 0.994077031

p_ni: 0.005909009

p_wrong: 0.000013961

Score: 0.554

Data Source: BioPlex,STRINGDB

MUC20

Tbio

Novelty: 0.07155729

p_int: 0.95164372

p_ni: 0.048332776

p_wrong: 0.000023504

Data Source: BioPlex

ADAMTS4

Tchem

Family: Enzyme

Novelty: 0.00578587

p_int: 0.946915717

p_ni: 0.00386059

p_wrong: 0.049223693

Score: 0.161

Data Source: BioPlex,STRINGDB

BRCA1

Tchem

Novelty: 0.00014684

Score: 0.992

Data Source: STRINGDB

BRCA2

Tbio

Novelty: 0.00031192

Score: 0.992

Data Source: STRINGDB

RAD51D

Tbio

Novelty: 0.02711092

Score: 0.991

Data Source: Reactome,STRINGDB

RAD1

Tchem

Novelty: 0.01108306

Score: 0.99

Data Source: STRINGDB

MRE11

Tbio

Novelty: 0.00847079

Score: 0.978

Data Source: STRINGDB

Publication Statistics

PubMed Score  91.75

PubMed score by year

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PubTator Score  72.33

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
ATP-binding
Chromosomal rearrangement
Complete proteome
DNA damage
DNA recombination
DNA repair
DNA-binding
Nucleotide-binding
Nucleus

GWAS Trait Find Similar Targets

age-related macular degeneration
allergic rhinitis
allergy
asthma
atrophic macular degeneration
balding measurement
biliary liver cirrhosis
BMI-adjusted waist-hip ratio
body height
breast carcinoma

MGI Phenotype Find Similar Targets

mortality/aging