Protein Classes
Protein Summary
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq, Jul 2008]
- ENST00000268261
- ENSP00000268261
- ENSG00000140650
- ENST00000566604
- ENSP00000456774
- PMI
- CDG1
- CDGS
- PMI1
- CDG1a
- PMM 2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.91 | ||
kinase perturbation | 0.76 | ||
transcription factor binding site profile | 0.76 | ||
tissue | 0.64 | ||
gene perturbation | 0.6 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.15 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.15 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (21)
Reactome (10)
KEGG (3)
PathwayCommons (4)
UniProt (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective PMM2 causes PMM2-CDG (CDG-1a) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with glycosylation precursor biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective PMM2 causes PMM2-CDG (CDG-1a) | ||||
Disease | ||||
Diseases associated with glycosylation precursor biosynthesis | ||||
Gene Ontology Terms (9)
Functions (1)
Components (3)
Processes (5)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (89)
1 – 10 of 89
PMM1
Family: Enzyme
Novelty: 0.032216
p_int: 1
Score: 0.902
Data Source: BioPlex,STRINGDB
MPI
Family: Enzyme
Novelty: 0.00966817
Score: 0.987
Data Source: STRINGDB
GMPPB
Family: Enzyme
Novelty: 0.05566338
Score: 0.969
Data Source: STRINGDB
GMPPA
Family: Enzyme
Novelty: 0.02186598
Score: 0.937
Data Source: STRINGDB
HK1
Family: Kinase
Novelty: 0.00089993
Score: 0.925
Data Source: STRINGDB
HK3
Family: Kinase
Novelty: 0.02597641
Score: 0.915
Data Source: STRINGDB
HKDC1
Family: Kinase
Novelty: 0.02926931
Score: 0.911
Data Source: STRINGDB
HK2
Family: Kinase
Novelty: 0.00222818
Score: 0.911
Data Source: STRINGDB
ALG2
Family: Enzyme
Novelty: 0.04124015
Score: 0.85
Data Source: STRINGDB
DPAGT1
Family: Enzyme
Novelty: 0.00248803
Score: 0.836
Data Source: STRINGDB
Publication Statistics
PubMed Score 131.15
PubMed score by year
PubTator Score 158.18
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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