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Tchem
GRM6
Metabotropic glutamate receptor 6

Protein Summary
Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phosph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231188
  • ENSP00000231188
  • ENSG00000113262
  • ENST00000517717
  • ENSP00000430767
  • ENST00000650031
  • ENSP00000497110

Symbol
  • GPRC1F
  • MGLUR6
  • mGlu6
  • CSNB1B
  • GPRC1F
  • MGLUR6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue sample
0.72
ligand (chemical)
0.7
cellular component
0.68
PubMedID
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.59   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.59   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Pathways (24)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Protein-Protein Interactions (311)
1 – 10 of 311
GNB3
Tbio
Novelty: 0.0037117
Score: 0.96
Data Source: STRINGDB
PCP2
Tdark
Novelty: 0.05083955
Score: 0.949
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.947
Data Source: STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.942
Data Source: STRINGDB
OPRM1
Tclin
Family: GPCR
Novelty: 0.0003701
Score: 0.936
Data Source: STRINGDB
DRD2
Tclin
Family: GPCR
Novelty: 0.00033797
Score: 0.931
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.927
Data Source: STRINGDB
DRD4
Tchem
Family: GPCR
Novelty: 0.00099622
Score: 0.927
Data Source: STRINGDB
OPRK1
Tclin
Family: GPCR
Novelty: 0.00171044
Score: 0.926
Data Source: STRINGDB
OPRD1
Tclin
Family: GPCR
Novelty: 0.00757692
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.59

PubMed score by year
PubTator Score  20.16

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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