GRM6
Metabotropic glutamate receptor 6
Protein Classes
Protein Summary
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phosph ...more
- ENST00000231188
- ENSP00000231188
- ENSG00000113262
- ENST00000517717
- ENSP00000430767
- ENST00000650031
- ENSP00000497110
- GPRC1F
- MGLUR6
- mGlu6
- CSNB1B
- GPRC1F
- MGLUR6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
tissue sample | 0.72 | ||
ligand (chemical) | 0.7 | ||
cellular component | 0.68 | ||
PubMedID | 0.62 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.59 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 330 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.59 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 330 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (17)
1 – 10 of 17
Pathways (24)
Reactome (6)
KEGG (3)
PathwayCommons (14)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Gene Ontology Terms (16)
Functions (3)
Components (6)
Processes (7)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Protein-Protein Interactions (311)
1 – 10 of 311
GNB3
Novelty: 0.0037117
Score: 0.96
Data Source: STRINGDB
PCP2
Novelty: 0.05083955
Score: 0.949
Data Source: STRINGDB
GNB5
Novelty: 0.0067714
Score: 0.947
Data Source: STRINGDB
GNGT1
Novelty: 0.05291961
Score: 0.942
Data Source: STRINGDB
OPRM1
Family: GPCR
Novelty: 0.0003701
Score: 0.936
Data Source: STRINGDB
DRD2
Family: GPCR
Novelty: 0.00033797
Score: 0.931
Data Source: STRINGDB
CNR1
Family: GPCR
Novelty: 0.00060063
Score: 0.927
Data Source: STRINGDB
DRD4
Family: GPCR
Novelty: 0.00099622
Score: 0.927
Data Source: STRINGDB
OPRK1
Family: GPCR
Novelty: 0.00171044
Score: 0.926
Data Source: STRINGDB
OPRD1
Family: GPCR
Novelty: 0.00757692
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score 131.59
PubMed score by year
PubTator Score 20.16
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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