GRM6
Metabotropic glutamate receptor 6
Protein Summary
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phosph ...more
- ENST00000231188
- ENSP00000231188
- ENSG00000113262
- ENST00000517717
- ENSP00000430767
- ENST00000650031
- ENSP00000497110
- GPRC1F
- MGLUR6
- mGlu6
- CSNB1B
- GPRC1F
- MGLUR6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
tissue sample | 0.72 | ||
ligand (chemical) | 0.7 | ||
cellular component | 0.68 | ||
PubMedID | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.49 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 330 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.49 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 330 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 18
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (18)
Protein-Protein Interactions (311)
Nearest Tclin Targets
Pathways (24)
Reactome (6)
KEGG (3)
PathwayCommons (14)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (6)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 1 | 1 | 1 | 59 | |||||
refractive error measurement | 1 | 1 | 1 | 31.4 | |||||
waist circumference | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 1 | 59 | |||||
refractive error measurement | 1 | 31.4 | |||||
waist circumference | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutamate metabotropic receptor 6 | VGNC:8623 | 462323 | |||||
Macaque | glutamate metabotropic receptor 6 | 713339 | ||||||
Mouse | MGI:1351343 | 108072 | ||||||
Rat | RGD:2747 | 24419 | ||||||
Dog | glutamate metabotropic receptor 6 | VGNC:41513 | 481452 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutamate metabotropic receptor 6 | |||||
Macaque | glutamate metabotropic receptor 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamate metabotropic receptor 6 | |||||
Publication Statistics
PubMed Score 134.49
PubMed score by year
PubTator Score 20.16
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (27)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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