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Tchem
ALOX15B
Arachidonate 15-lipoxygenase B

Protein Summary
Description
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effect ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380173
  • ENSP00000369520
  • ENSG00000179593
  • ENST00000380183
  • ENSP00000369530
  • ENST00000573359
  • ENSP00000460332

Symbol
  • 15-LOX-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.83
gene perturbation
0.76
cellular component
0.72
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.72   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.72   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (64)
KBTBD2
Tdark
Novelty:  0.50755656
p_int:  0.999999544
p_ni:  1.6e-8
p_wrong:  4.4e-7
Score:  0.416
Data Source:  BioPlex,STRINGDB
RPH3A
Tbio
Family:  Epigenetic
Novelty:  0.01321524
p_int:  0.998054085
p_ni:  0.001924213
p_wrong:  0.000021702
Score:  0.209
Data Source:  BioPlex,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.993167821
p_ni:  0.006352116
p_wrong:  0.000480064
Score:  0.179
Data Source:  BioPlex,STRINGDB
TAF5L
Tbio
Family:  Enzyme
Novelty:  0.29525944
p_int:  0.966599028
p_ni:  0.033294986
p_wrong:  0.000105986
Score:  0.188
Data Source:  BioPlex,STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.958543674
p_ni:  0.041456239
p_wrong:  8.8e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
PTGS1
Tclin
Family:  Enzyme
Novelty:  0.00043214
Score:  0.946
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.942
Data Source:  STRINGDB
CYP4F2
Tchem
Family:  Enzyme
Novelty:  0.0050361
Score:  0.918
Data Source:  STRINGDB
CYP4F3
Tbio
Family:  Enzyme
Novelty:  0.01392719
Score:  0.917
Data Source:  STRINGDB
CYP2C8
Tchem
Novelty:  0.00186373
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (12)
Arachidonic acid metabolism (R-HSA-2142753)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of 15-eicosatetraenoic acid derivatives
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of 15-eicosatetraenoic acid derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
21.2
blood protein measurement
1
1
1
11.4
mathematical ability
2
1
2
8.3
reticulocyte measurement
1
1
1
8.2
chronotype measurement
1
1
1
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
21.2
blood protein measurement
1
11.4
mathematical ability
2
8.3
reticulocyte measurement
1
8.2
chronotype measurement
1
8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arachidonate 15-lipoxygenase, type B
VGNC:9150
455104
Macaque
arachidonate 15-lipoxygenase, type B
716764
Mouse
MGI:1098228
11688
Rat
RGD:628809
266604
Dog
arachidonate 15-lipoxygenase, type B
VGNC:37812
489485
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arachidonate 15-lipoxygenase, type B
Macaque
arachidonate 15-lipoxygenase, type B
Mouse
Rat
Dog
arachidonate 15-lipoxygenase, type B
Publication Statistics
PubMed Score 73.72
PubMed score by year
PubTator Score 60.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title