Tchem ALOX15B Arachidonate 15-lipoxygenase B

Protein Summary

Description

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15296
• D3DTR2
• Q8IYQ2
• Q8TEV3
• Q8TEV4
• Q8TEV5
• Q8TEV6
• Q9UKM4
• 15-LOX-B

Gene Name

• ALOX15B

Ensembl ID

• ENST00000380173
• ENSP00000369520
• ENSG00000179593
• ENST00000380183
• ENSP00000369530
• ENST00000573359
• ENSP00000460332

Symbol

• 15-LOX-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
biological process	0.83
gene perturbation	0.76
cellular component	0.72
tissue sample	0.61

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Arachidonate 15-lipoxygenase B

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Arachidonate 15-lipoxygenase B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.72   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.72   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0