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Tchem
OGT
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Protein Summary
Description
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373701
  • ENSP00000362805
  • ENSG00000147162
  • ENST00000373719
  • ENSP00000362824

Symbol
  • OGT1
  • HRNT1
  • MRX106
  • HINCUT-1
  • O-GLCNAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
virus perturbation
0.98
PubMedID
0.97
transcription factor perturbation
0.96
molecular function
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.34   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.34   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (208)
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.996629581
p_ni:  0.003370419
Score:  0.735
Data Source:  BioPlex,STRINGDB
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.992366999
p_ni:  0.007633001
Score:  0.345
Data Source:  BioPlex,STRINGDB
CREB3
Tbio
Family:  TF
Novelty:  0.00424318
p_int:  0.986339533
p_ni:  0.013660467
Score:  0.656
Data Source:  BioPlex,STRINGDB
BAP1
Tbio
Family:  Enzyme
Novelty:  0.00501435
p_int:  0.98473171
p_ni:  0.01526829
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
DIDO1
Tbio
Family:  Epigenetic
Novelty:  0.0492858
p_int:  0.981408321
p_ni:  0.018591679
Score:  0.262
Data Source:  BioPlex,STRINGDB
THAP11
Tbio
Family:  TF
Novelty:  0.0679686
p_int:  0.954983361
p_ni:  0.045016639
Score:  0.325
Data Source:  BioPlex,STRINGDB
DDAH2
Tbio
Family:  Enzyme
Novelty:  0.00355931
p_int:  0.951918029
p_ni:  0.048081971
Score:  0.228
Data Source:  BioPlex,STRINGDB
CIART
Tbio
Novelty:  0.09567981
p_int:  0.933361519
p_ni:  0.066638481
Score:  0.345
Data Source:  BioPlex,STRINGDB
HCFC1R1
Tbio
Novelty:  2.97633658
p_int:  0.891147665
p_ni:  0.108852335
Score:  0.269
Data Source:  BioPlex,STRINGDB
HCFC2
Tbio
Novelty:  0.12260416
p_int:  0.880526121
p_ni:  0.119473879
Score:  0.814
Data Source:  BioPlex,STRINGDB
Pathways (12)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
45.7
body height
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
45.7
body height
1
2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
O-linked N-acetylglucosamine (GlcNAc) transferase
698268
Mouse
MGI:1339639
108155
Rat
RGD:62060
26295
Dog
O-linked N-acetylglucosamine (GlcNAc) transferase
480955
Horse
O-linked N-acetylglucosamine (GlcNAc) transferase
100056148
Species
Name
OMA
EggNOG
Inparanoid
Macaque
O-linked N-acetylglucosamine (GlcNAc) transferase
Mouse
Rat
Dog
O-linked N-acetylglucosamine (GlcNAc) transferase
Horse
O-linked N-acetylglucosamine (GlcNAc) transferase
Publication Statistics
PubMed Score 368.34
PubMed score by year
PubTator Score 590.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title