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Tchem
OGT
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

Protein Summary
Description
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373701
  • ENSP00000362805
  • ENSG00000147162
  • ENST00000373719
  • ENSP00000362824

Symbol
  • OGT1
  • HRNT1
  • MRX106
  • HINCUT-1
  • O-GLCNAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
virus perturbation
0.98
PubMedID
0.97
transcription factor perturbation
0.96
molecular function
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1105.86   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1105.86   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3695712
chemical structure image
Protein Data Bank (33)
1 – 5 of 33
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
Metabolism of proteins
Protein-Protein Interactions (208)
1 – 10 of 208
TRAK2
Tbio
Novelty: 0.07192089
p_int: 0.996629581
p_ni: 0.003370419
Score: 0.735
Data Source: BioPlex,STRINGDB
NUP62CL
Tdark
p_int: 0.992366999
p_ni: 0.007633001
Score: 0.345
Data Source: BioPlex,STRINGDB
CREB3
Tbio
Family: TF
Novelty: 0.00516251
p_int: 0.986339533
p_ni: 0.013660467
Score: 0.656
Data Source: BioPlex,STRINGDB
BAP1
Tbio
Family: Enzyme
Novelty: 0.00594927
p_int: 0.98473171
p_ni: 0.01526829
Score: 0.962
Data Source: BioPlex,Reactome,STRINGDB
DIDO1
Tbio
Family: Epigenetic
Novelty: 0.0526149
p_int: 0.981408321
p_ni: 0.018591679
Score: 0.262
Data Source: BioPlex,STRINGDB
THAP11
Tbio
Family: TF
Novelty: 0.06994842
p_int: 0.954983361
p_ni: 0.045016639
Score: 0.325
Data Source: BioPlex,STRINGDB
DDAH2
Tbio
Family: Enzyme
Novelty: 0.00402983
p_int: 0.951918029
p_ni: 0.048081971
Score: 0.228
Data Source: BioPlex,STRINGDB
CIART
Tbio
Novelty: 0.00335302
p_int: 0.933361519
p_ni: 0.066638481
Score: 0.345
Data Source: BioPlex,STRINGDB
HCFC1R1
Tbio
p_int: 0.891147665
p_ni: 0.108852335
Score: 0.269
Data Source: BioPlex,STRINGDB
HCFC2
Tbio
Novelty: 0.2
p_int: 0.880526121
p_ni: 0.119473879
Score: 0.814
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1105.86

PubMed score by year
PubTator Score  590.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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