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Tbio
ATXN7
Ataxin-7

Protein Summary
Description
Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000484332
  • ENSP00000428277
  • ENSG00000163635
  • ENST00000487717
  • ENSP00000420234
  • ENST00000522345
  • ENSP00000428067
  • ENST00000538065
  • ENSP00000439585

Symbol
  • SCA7
  • SCA7
  • OPCA3
  • SGF73
  • ADCAII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
microRNA
0.81
biological process
0.8
transcription factor
0.79
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.8   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.8   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
ATXN7L3
Tbio
Novelty:  0.1572083
p_int:  0.999999999
p_ni:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.99999998
p_ni:  1.8e-8
p_wrong:  2e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
TAF6L
Tdark
Family:  Enzyme
Novelty:  0.7411477
p_int:  0.999996547
p_ni:  0.000003407
p_wrong:  4.6e-8
Score:  0.969
Data Source:  BioPlex,STRINGDB
SUPT20H
Tbio
Novelty:  0.00625899
p_int:  0.999950328
p_ni:  0.000003425
p_wrong:  0.000046248
Score:  0.987
Data Source:  BioPlex,STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
Score:  0.996
Data Source:  STRINGDB
TRRAP
Tbio
Novelty:  0.01517245
Score:  0.995
Data Source:  STRINGDB
TAF10
Tbio
Novelty:  0.0276004
Score:  0.994
Data Source:  STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
Score:  0.99
Data Source:  STRINGDB
SUPT3H
Tbio
Novelty:  0.13202683
Score:  0.989
Data Source:  STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
4
1.1
95.5
glomerular filtration rate
2
2
2
77.6
8
3
2
1.1
61.3
red blood cell distribution width
1
1
1
48.5
diastolic blood pressure
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
95.5
glomerular filtration rate
2
77.6
2
1.1
61.3
red blood cell distribution width
1
48.5
diastolic blood pressure
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2179277
246103
Rat
RGD:1562692
361015
Dog
ataxin 7
VGNC:38303
484701
Horse
ataxin 7
VGNC:15696
100055963
Cow
ataxin 7
VGNC:26342
536833
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ataxin 7
Horse
ataxin 7
Cow
ataxin 7
Publication Statistics
PubMed Score 335.80
PubMed score by year
PubTator Score 253.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title