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Tchem
MAPK13
Mitogen-activated protein kinase 13

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an importan ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211287
  • ENSP00000211287
  • ENSG00000156711
  • ENST00000373766
  • ENSP00000362871

Symbol
  • PRKM13
  • SAPK4
  • SAPK4
  • PRKM13
  • MAPK 13
  • MAPK-13
  • p38delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
hub protein
0.92
protein domain
0.85
gene perturbation
0.82
interacting protein
0.79


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.83   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 767   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.83   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 767   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (32)
1 – 10 of 32
CHEMBL574738
chemical structure image
CHEMBL103667
chemical structure image
CHEMBL1938400
chemical structure image
CHEMBL561932
chemical structure image
CHEMBL2087507
chemical structure image
CHEMBL3895054
chemical structure image
CHEMBL2087502
chemical structure image
CHEMBL2087504
chemical structure image
CHEMBL2087745
chemical structure image
CHEMBL2087508
chemical structure image
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 13
VGNC:7195
462644
Macaque
mitogen-activated protein kinase 13
719085
Mouse
MGI:1346864
26415
Rat
RGD:3045
29513
Dog
mitogen-activated protein kinase 13
VGNC:42994
612821
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 13
Macaque
mitogen-activated protein kinase 13
Mouse
Rat
Dog
mitogen-activated protein kinase 13
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15264-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (114)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
DSCAM interactions
Reactome
Developmental Biology
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
DSCAM interactions
Developmental Biology
Immune System
Innate Immune System
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (196)
1 – 10 of 196
MAPK12
Tchem
Family: Kinase
Novelty: 0.00835017
p_int: 0.999989179
p_ni: 1e-9
p_wrong: 0.00001082
Score: 0.948
Data Source: BioPlex,STRINGDB
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.977236815
p_ni: 0.022763185
Score: 0.37
Data Source: BioPlex,STRINGDB
MAPKAPK3
Tchem
Family: Kinase
Novelty: 0.02469147
Score: 0.985
Data Source: STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.977
Data Source: STRINGDB
MAPKAPK2
Tchem
Family: Kinase
Novelty: 0.00486452
Score: 0.97
Data Source: STRINGDB
MAP2K3
Tchem
Family: Kinase
Novelty: 0.00349605
Score: 0.965
Data Source: STRINGDB
ATF2
Tbio
Family: TF
Novelty: 0.00457832
Score: 0.962
Data Source: STRINGDB
EEF2K
Tchem
Family: Kinase
Novelty: 0.02271177
Score: 0.951
Data Source: STRINGDB
MAPT
Tchem
Novelty: 0.00013232
Score: 0.939
Data Source: STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.83

PubMed score by year
PubTator Score  43.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer