Protein Summary
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036). Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
- ENST00000302247
- ENSP00000303532
- ENSG00000171711
- ENST00000318157
- ENSP00000424598
- ENSG00000177257
- ENST00000617136
- ENSP00000479138
- ENSG00000275444
- ENST00000642856
- ENSP00000496499
- ENSG00000285181
- ENST00000644124
- ENSP00000493760
- ENSG00000285433
- DEFB102
- DEFB2
- DEFB4
- DEFB4P
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.99 | ||
cell type or tissue | 0.61 | ||
tissue | 0.57 | ||
disease | 0.56 | ||
phenotype | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 146.07 (req: < 5)
Gene RIFs: 260 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 146.07 (req: >= 5)
Gene RIFs: 260 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0