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Tbio
DEFB4A
Beta-defensin 4A

Protein Summary
Description
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036). Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302247
  • ENSP00000303532
  • ENSG00000171711
  • ENST00000318157
  • ENSP00000424598
  • ENSG00000177257
  • ENST00000617136
  • ENSP00000479138
  • ENSG00000275444
  • ENST00000642856
  • ENSP00000496499
  • ENSG00000285181
  • ENST00000644124
  • ENSP00000493760
  • ENSG00000285433

Symbol
  • DEFB102
  • DEFB2
  • DEFB4
  • DEFB4P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
cell type or tissue
0.61
tissue
0.57
disease
0.56
phenotype
0.5


Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.36   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.36   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15263-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (28)
1 – 10 of 28
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
p_int:  0.980841365
p_ni:  0.019158601
p_wrong:  3.4e-8
Data Source:  BioPlex
SPAG11B
Tbio
Novelty:  0.07935181
Score:  0.742
Data Source:  STRINGDB
SPAG11A
Tbio
Novelty:  0.18350821
Score:  0.742
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.679
Data Source:  STRINGDB
DEFA3
Tbio
Novelty:  0.04840173
Score:  0.626
Data Source:  STRINGDB
DEFA4
Tbio
Novelty:  0.04566082
Score:  0.625
Data Source:  STRINGDB
S100A7
Tbio
Novelty:  0.00434262
Score:  0.601
Data Source:  STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
Score:  0.58
Data Source:  STRINGDB
CAMP
Tbio
Novelty:  0.00064433
Score:  0.58
Data Source:  STRINGDB
DEFB104A
Tbio
Novelty:  0.0468791
Score:  0.56
Data Source:  STRINGDB
Publication Statistics
PubMed Score  131.36

PubMed score by year
PubTator Score  97.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer