Tbio SURF4 Surfeit locus protein 4

Protein Summary

Description

May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O15260
• B7Z6A4
• O60923
• Q5T8U6
• Q9UNZ0
• Q9UNZ1

Gene Name

• SURF4

Ensembl ID

• ENST00000371989
• ENSP00000361057
• ENSG00000148248
• ENST00000485435
• ENSP00000419853
• ENST00000545297
• ENSP00000446061
• ENST00000626303
• ENSP00000487537
• ENSG00000280951
• ENST00000629119
• ENSP00000486869
• ENST00000629578
• ENSP00000486049

Symbol

• SURF-4
• ERV29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
kinase perturbation	0.96
virus perturbation	0.94
interacting protein	0.9
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Surfeit Locus Protein 4

Protein / Oxidoreductase / Oxidase / Surfeit Locus Protein 4

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Surfeit Locus Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.81   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.81   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0