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Tbio
SURF4
Surfeit locus protein 4

Protein Summary
Description
May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371989
  • ENSP00000361057
  • ENSG00000148248
  • ENST00000485435
  • ENSP00000419853
  • ENST00000545297
  • ENSP00000446061
  • ENST00000626303
  • ENSP00000487537
  • ENSG00000280951
  • ENST00000629119
  • ENSP00000486869
  • ENST00000629578
  • ENSP00000486049

Symbol
  • SURF-4
  • ERV29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
kinase perturbation
0.96
virus perturbation
0.94
interacting protein
0.9
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.94   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.94   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (314)
Items per page:
1 – 5 of 314
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
13
13
36
2.9
99.8
low density lipoprotein cholesterol measurement
13
13
36
2.9
99.8
alkaline phosphatase measurement
6
8
8
8.8
99.7
alkaline phosphatase measurement
6
8
8
8.8
99.7
venous thromboembolism
9
10
2
1.5
99.7
Items per page:
1 – 5 of 314
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
36
2.9
99.8
low density lipoprotein cholesterol measurement
36
2.9
99.8
alkaline phosphatase measurement
8
8.8
99.7
alkaline phosphatase measurement
8
8.8
99.7
venous thromboembolism
2
1.5
99.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
surfeit 4
VGNC:14397
100608057
Macaque
surfeit 4
100429963
Mouse
MGI:98445
20932
Dog
surfeit 4
VGNC:46996
491269
Chicken
surfeit 4
CGNC:66188
374273
Species
Name
OMA
EggNOG
Inparanoid
Chimp
surfeit 4
Macaque
surfeit 4
Mouse
Dog
surfeit 4
Chicken
surfeit 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15260-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Immune System
Innate Immune System
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (13)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (244)
1 – 10 of 244
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.97771794
p_ni:  0.02228206
Score:  0.155
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.965029123
p_ni:  0.034970877
Score:  0.375
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.947512433
p_ni:  0.052487567
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.776957845
p_ni:  0.223042155
Data Source:  BioPlex
KDELR1
Tbio
Novelty:  0.0036468
Score:  0.975
Data Source:  STRINGDB
TMED10
Tbio
Novelty:  0.02742083
Score:  0.966
Data Source:  Reactome,STRINGDB
KDELR2
Tbio
Novelty:  0.12002642
Score:  0.965
Data Source:  STRINGDB
TMED2
Tbio
Novelty:  0.03731104
Score:  0.962
Data Source:  Reactome,STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.956
Data Source:  STRINGDB
TMED7
Tdark
Novelty:  0.31193294
Score:  0.955
Data Source:  STRINGDB
Publication Statistics
PubMed Score  35.94

PubMed score by year
PubTator Score  4.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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