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Tbio
NPHP1
Nephrocystin-1

Protein Summary
Description
Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localize ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316534
  • ENSP00000313169
  • ENSG00000144061
  • ENST00000355301
  • ENSP00000347452
  • ENST00000393272
  • ENSP00000376953
  • ENST00000445609
  • ENSP00000389879

Symbol
  • NPH1
  • NPH1
  • JBTS4
  • SLSN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.82
cell type or tissue
0.75
cellular component
0.72
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.79   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.79   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nephrocystin 1
VGNC:10444
459483
Macaque
nephrocystin 1
696218
Mouse
MGI:1858233
53885
Dog
nephrocystin 1
VGNC:43918
403780
Horse
nephrocystin 1
VGNC:20836
100051808
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nephrocystin 1
Macaque
nephrocystin 1
Mouse
Dog
nephrocystin 1
Horse
nephrocystin 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15259-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (201)
1 – 10 of 201
KCNA5
Tclin
Family: IC
Novelty: 0.00182891
p_int: 0.999984928
p_ni: 0.000014997
p_wrong: 7.5e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
DNAJC7
Tbio
Novelty: 0.02133191
p_int: 0.999979188
p_ni: 0.000020218
p_wrong: 5.93e-7
Data Source: BioPlex
RPGR
Tbio
Family: Enzyme
Novelty: 0.002733
p_int: 0.99992892
p_ni: 0.000056743
p_wrong: 0.000014336
Score: 0.948
Data Source: BioPlex,STRINGDB
NPHP4
Tbio
Novelty: 0.02873746
Score: 0.999
Data Source: Reactome,STRINGDB
AHI1
Tbio
Novelty: 0.01180688
Score: 0.995
Data Source: STRINGDB
RPGRIP1L
Tbio
Novelty: 0.00819421
Score: 0.993
Data Source: Reactome,STRINGDB
TMEM67
Tbio
Novelty: 0.02573267
Score: 0.992
Data Source: STRINGDB
CEP290
Tbio
Novelty: 0.00526375
Score: 0.991
Data Source: STRINGDB
CC2D2A
Tbio
Novelty: 0.03684487
Score: 0.99
Data Source: STRINGDB
TMEM216
Tbio
Novelty: 0.07870718
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  87.79

PubMed score by year
PubTator Score  73.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer