You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RER1
Protein RER1

Protein Summary
Description
Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000488353
  • ENSP00000464222
  • ENSG00000157916
  • ENST00000605895
  • ENSP00000475168
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.9
histone modification site profile
0.72
cellular component
0.68
tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.59   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.59   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (92)
1 – 10 of 92
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.922569634
p_ni:  0.077430366
Data Source:  BioPlex
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.850876671
p_ni:  0.149123329
Score:  0.179
Data Source:  BioPlex,STRINGDB
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.823587309
p_ni:  0.176409871
p_wrong:  0.00000282
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.758627788
p_ni:  0.241369743
p_wrong:  0.00000247
Score:  0.177
Data Source:  BioPlex,STRINGDB
BCAP31
Tbio
Novelty:  0.01363316
Score:  0.955
Data Source:  STRINGDB
ATP5MG
Tbio
Family:  Enzyme
Novelty:  0.16555751
Score:  0.885
Data Source:  STRINGDB
ATP5PO
Tbio
Family:  Enzyme
Novelty:  0.01038964
Score:  0.878
Data Source:  STRINGDB
STX12
Tbio
Novelty:  0.03836262
Score:  0.873
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.868
Data Source:  STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
Score:  0.861
Data Source:  STRINGDB
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
4
5
87.7
alkaline phosphatase measurement
2
2
1
8.1
85.6
4
2
0
1.1
63.9
mean corpuscular hemoglobin concentration
1
1
1
53.3
1
1
0
1.4
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
87.7
alkaline phosphatase measurement
1
8.1
85.6
0
1.1
63.9
mean corpuscular hemoglobin concentration
1
53.3
0
1.4
52.4
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retention in endoplasmic reticulum sorting receptor 1
VGNC:11023
743842
Macaque
retention in endoplasmic reticulum sorting receptor 1
694540
Mouse
MGI:1915080
67830
Rat
RGD:1306324
298675
Dog
retention in endoplasmic reticulum sorting receptor 1
VGNC:45476
479578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retention in endoplasmic reticulum sorting receptor 1
Macaque
retention in endoplasmic reticulum sorting receptor 1
Mouse
Rat
Dog
retention in endoplasmic reticulum sorting receptor 1
Publication Statistics
PubMed Score 40.59
PubMed score by year
PubTator Score 36.48
PubTator score by year