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Tbio
CLIC2
Chloride intracellular channel protein 2

Protein Summary
Description
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369449
  • ENSP00000358460
  • ENSG00000155962

Symbol
  • CLIC2b
  • MRXS32
  • XAP121
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.73
interacting protein
0.72
tissue sample
0.63
biological process
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.45   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.45   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1
0
1.1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
0
1.1
3.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride intracellular channel 2
VGNC:12259
107971252
Macaque
chloride intracellular channel 2
703475
Rat
RGD:1306580
294141
Dog
chloride intracellular channel 2
VGNC:39338
492270
Horse
chloride intracellular channel 2
VGNC:16611
100062829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride intracellular channel 2
Macaque
chloride intracellular channel 2
Rat
Dog
chloride intracellular channel 2
Horse
chloride intracellular channel 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15247-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Muscle contraction
Stimuli-sensing channels
Protein-Protein Interactions (71)
1 – 10 of 71
CLIC5
Tbio
Family:  IC
Novelty:  0.05504841
p_int:  0.999996385
p_ni:  6e-9
p_wrong:  0.000003609
Score:  0.973
Data Source:  BioPlex,STRINGDB
CLIC4
Tbio
Family:  IC
Novelty:  0.01088335
p_int:  0.999747957
p_ni:  1.15e-7
p_wrong:  0.000251929
Score:  0.959
Data Source:  BioPlex,STRINGDB
MAPK15
Tchem
Family:  Kinase
Novelty:  0.02414054
Score:  0.8
Data Source:  STRINGDB
TTYH2
Tbio
Family:  IC
Novelty:  0.19796461
Score:  0.727
Data Source:  STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
Score:  0.706
Data Source:  STRINGDB
RYR1
Tclin
Family:  IC
Novelty:  0.00077827
Score:  0.655
Data Source:  STRINGDB
BEST4
Tbio
Family:  IC
Novelty:  0.06102944
Score:  0.636
Data Source:  STRINGDB
IGSF3
Tbio
Novelty:  0.07528465
Score:  0.634
Data Source:  STRINGDB
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
Score:  0.626
Data Source:  STRINGDB
BEST3
Tbio
Family:  IC
Novelty:  0.03481733
Score:  0.623
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.45

PubMed score by year
PubTator Score  17.01

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer