You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SLC22A1
Solute carrier family 22 member 1

Protein Summary
Description
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epith ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324965
  • ENSP00000318103
  • ENSG00000175003
  • ENST00000366963
  • ENSP00000355930
  • ENST00000457470
  • ENSP00000409557
  • ENST00000460902
  • ENSP00000439274
  • ENST00000642587
  • ENSP00000495844

Symbol
  • OCT1
  • OCT1
  • HOCT1
  • oct1_cds
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.91
chemical
0.89
cell type or tissue
0.76
trait
0.75


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.73   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.73   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
12
15
11.8
99.3
low density lipoprotein cholesterol measurement
5
16
23
2.3
98.8
creatinine measurement
6
11
13
98.8
apolipoprotein B measurement
2
13
14
98.5
total cholesterol measurement
6
17
23
2.4
98.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
15
11.8
99.3
low density lipoprotein cholesterol measurement
23
2.3
98.8
creatinine measurement
13
98.8
apolipoprotein B measurement
14
98.5
total cholesterol measurement
23
2.4
98.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 1
VGNC:7917
472177
Macaque
solute carrier family 22 member 1
703449
Mouse
MGI:108111
20517
Rat
RGD:3224
24904
Dog
solute carrier family 22 member 1
VGNC:46270
484068
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 1
Macaque
solute carrier family 22 member 1
Mouse
Rat
Dog
solute carrier family 22 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15245-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Abacavir transmembrane transport (R-HSA-2161517)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abacavir transmembrane transport
Reactome
Abacavir transport and metabolism
Reactome
Metabolism
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Abacavir transmembrane transport
Abacavir transport and metabolism
Metabolism
Na+/Cl- dependent neurotransmitter transporters
Neuronal System
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (49)
1 – 10 of 49
SPNS3
Tdark
Novelty:  0.40832952
Score:  0.908
Data Source:  STRINGDB
SLC47A1
Tchem
Family:  Transporter
Novelty:  0.00535064
Score:  0.839
Data Source:  STRINGDB
CERS2
Tbio
Family:  TF
Novelty:  0.00994797
Score:  0.829
Data Source:  STRINGDB
SLC47A2
Tchem
Family:  Transporter
Novelty:  0.01171254
Score:  0.788
Data Source:  STRINGDB
SLC28A1
Tbio
Family:  Transporter
Novelty:  0.00745854
Score:  0.756
Data Source:  STRINGDB
SLCO1B3
Tchem
Family:  Transporter
Novelty:  0.0031518
Score:  0.753
Data Source:  STRINGDB
SLCO1B1
Tchem
Family:  Transporter
Novelty:  0.00126613
Score:  0.737
Data Source:  STRINGDB
SLC28A2
Tchem
Family:  Transporter
Novelty:  0.00967399
Score:  0.72
Data Source:  STRINGDB
ABCG2
Tchem
Family:  Transporter
Novelty:  0.00029779
Score:  0.719
Data Source:  STRINGDB
ASGR2
Tbio
Novelty:  0.14671716
Score:  0.718
Data Source:  STRINGDB
Publication Statistics
PubMed Score  267.73

PubMed score by year
PubTator Score  591.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: