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Tbio
LEPROT
Leptin receptor gene-related protein

Protein Summary
Description
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371065
  • ENSP00000360104
  • ENSG00000213625

Symbol
  • LEPR
  • OBR
  • LEPR
  • VPS55
  • OBRGRP
  • OB-RGRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.97
kinase perturbation
0.84
histone modification site profile
0.63
transcription factor binding site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.81   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.81   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (12)
1 – 10 of 12
TMEM50A
Tdark
Novelty:  0.41718286
Score:  0.91
Data Source:  STRINGDB
LEPR
Tclin
Novelty:  0.00070587
Score:  0.791
Data Source:  STRINGDB
TMEM50B
Tdark
Novelty:  0.32170627
Score:  0.667
Data Source:  STRINGDB
RAB13
Tbio
Family:  Enzyme
Novelty:  0.02465609
Score:  0.589
Data Source:  STRINGDB
GHR
Tclin
Novelty:  0.00105635
Score:  0.537
Data Source:  STRINGDB
SEC16B
Tbio
Novelty:  0.04073621
Score:  0.473
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.473
Data Source:  STRINGDB
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
Score:  0.45
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.426
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.426
Data Source:  STRINGDB
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
10
10
99.7
testosterone measurement
3
3
3
85.6
neutrophil count
2
2
2
84.1
leukocyte count
2
2
2
78.7
body mass index
5
1
5
73.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
10
99.7
testosterone measurement
3
85.6
neutrophil count
2
84.1
leukocyte count
2
78.7
body mass index
5
73.9
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leptin receptor overlapping transcript
VGNC:11507
101057790
Mouse
MGI:2687005
230514
Rat
RGD:621034
56766
Dog
leptin receptor overlapping transcript
VGNC:42639
609115
Horse
leptin receptor overlapping transcript
VGNC:19634
100630509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leptin receptor overlapping transcript
Mouse
Rat
Dog
leptin receptor overlapping transcript
Horse
leptin receptor overlapping transcript
Publication Statistics
PubMed Score 16.81
PubMed score by year
PubTator Score 9.53
PubTator score by year